罗沙司他治疗肾性贫血不良反应的研究进展  

Research progress on adverse effects of roxadustat for renal anemia

作　　者：黄爱芳[1] 潘玲[1] 周红卫[1] 黄媛[1] 韦潇潇 霍冬梅[1] HUANG Aifang;PAN Ling;ZHOU Hongwei;HUANG Yuan;WEI Xiaoxiao;HUO Dongmei(Department of Nephrology,the First Affiliated Hospital of Guangxi Medical University,Nanning City,Guangxi Zhuang Autonomous Region,530021,China)

机构地区：[1]广西医科大学第一附属医院肾内科,广西南宁530021

出　　处：《蛇志》2024年第2期235-241,共7页Journal of Snake

摘　　要：罗沙司他是治疗肾性贫血的一种新型口服药物,主要通过作用于缺氧诱导因子(HIF)通路,促进内源性促红细胞生成素(EPO)的产生及其受体的表达,优化铁的利用等机制,起到升高血红蛋白的作用。然而,罗沙司他在纠正肾性贫血的同时,可能导致深静脉血栓形成、动静脉内瘘血栓形成、高血压、高钾血症等不良反应风险的增加。因此,临床应用罗沙司他时,应加强对患者血管通路、血压、电解质等的监测,及时发现和处理相关不良反应,确保患者的用药安全。Roxadustat is a novel oral medication for the treatment of renal anemia.It can not only promote the production of endogenous erythropoietin(EPO)and the expression of its receptor,but also optimize the utilization of iron,playing a role in increasing hemoglobin.However,using of Roxadustat may lead to an increased risk of adverse effects such as deep vein thrombosis,arteriovenous fistula thrombosis,hypertension and hyperkalemia,etc.Clinicians should strengthen the monitoring of patients'vascular access,blood pressure,electrolytes,etc,when using Roxadustat to ensure the safety of patients.

关 键 词：罗沙司他 肾性贫血 不良反应 

分 类 号：R453[医药卫生—治疗学] R556[医药卫生—临床医学]