高效液相色谱—串联质谱法测定饮用水中季铵盐类消毒剂的不确定度评定  

Evaluation of uncertainty in determination of two quaternary ammonium salt disinfectants in drinking water by high-performance liquid chromatography tandem mass spectrometry

作　　者：张雪梅[1] 孔祥吉 田丰 ZHANG Xuemei;KONG Xiangji;TIAN Feng(Jiangsu Institute of Metrology,Nanjing,Jiangsu 210023,China;Nanjing Institute of Environmental Science,Ministry of Ecology and Environment of the People s Republic of China,Nanjing,Jiangsu 210042,China;Key Laboratory of Pesticide Environmental Assessment and Pollution Control,Ministry of Ecology and Environment of the People s Republic of China,Nanjing,Jiangsu 210042,China)

机构地区：[1]江苏省计量科学研究院,江苏南京210023 [2]生态环境部南京环境科学研究所,江苏南京210042 [3]国家环境保护农药环境评价与污染控制重点实验室,江苏南京210042

出　　处：《食品与机械》2024年第6期77-82,89,共7页Food and Machinery

基　　金：江苏省基础研究计划自然科学基金—面上项目(编号:BK20231114)。

摘　　要：[目的]为做好高效液相色谱—串联质谱法测定饮用水中癸甲氯胺、苯扎氯铵消毒剂残留量的质量控制,促进检测方法的改进。[方法]通过建立数学模型和不确定度来源鱼骨图,评估引入的不确定度分量,计算合成标准不确定度和扩展不确定度。[结果]取包含因子k=2,当饮用水样中癸甲氯胺、苯扎氯铵残留量分别为4.3,4.7μg/L时,其扩展不确定度U分别为0.52,0.48μg/L。[结论]采用高效液相色谱—串联质谱法测定饮用水中癸甲氯胺、苯扎氯铵,其不确定度主要来源于系列标准溶液配制、测定重复性、仪器校准等分量。[Objective]To achieve good internal quality control of determination of decamethylammonium chloride and benzalkonium chloride residues in drinking water by high performance liquid chromatography tandem mass spectrometry,and to promote the improvement of detection methods.[Methods]A mathematical model and fishbone diagram were established to evaluate the introduced uncertainty components,and the combined standard uncertainty and expanded uncertainty were calculated.[Results]Under the inclusion factor k=2,and the decamethylammonium chloride and benzalkonium chloride residue in drinking water samples was 4.3μg/L and 4.7μg/L and their expanded uncertainty U was 0.52μg/L and 0.48μg/L,respectively.[Conclusion]The uncertainty in determining the two disinfectants with high performance liquid chromatography tandem mass spectrometry mainly comes from the preparation of the series standard solutions,determination repeatability,and instrument calibration,etc.

关 键 词：消毒剂 季铵盐 液相色谱—串联质谱法 不确定度 

分 类 号：O657.63[理学—分析化学] TU991.21[理学—化学]