手足低温法预防盐酸多柔比星脂质体致手足综合征的效果  

Effect of local cold compress in the prevention of pegylated liposomal doxorubicin induced hand-foot syndrome

作　　者：史素芳[1] 贾东晓 韩建军[1] 赵红祥 任雁飞 李俊娇 Shi Sufang;Jia Dongxiao;Han Jianjun;Zhao Hongxiang;Ren Yanfei;Li Junjiao(Department of Thyroid and Breast SurgeryⅡ,Affiliated Hospital of Hebei Engineering University,Handan 056002,China;Department of Operating Room,Affiliated Hospital of Hebei Engineering University,Handan 056002,China;First Department of Emergency,Affiliated Hospital of Hebei Engineering University,Handan 056002,China)

机构地区：[1]河北工程大学附属医院乳腺外二科,河北邯郸056002 [2]河北工程大学附属医院手术室,河北邯郸056002 [3]河北工程大学附属医院急诊一科,河北邯郸056002

出　　处：《临床荟萃》2024年第6期537-541,共5页Clinical Focus

基　　金：2021年度河北省医学科学研究课题计划项目——TUFT1/RILPL2/PTEN通路在乳腺癌增殖和转移中作用机制的研究(N20210206);邯郸市科技局项目——优化乳腺癌多柔比星脂质体化疗致皮肤毒性的研究(2021-2060499-360)。

摘　　要：目的 从临床角度探究局部冷敷法在盐酸多柔比星脂质体(PLD)致相关手足综合征(HFS)中的应用效果。方法 采取非同期随机对照试验,选取2021年6月至2023年6月河北工程大学附属医院乳腺外科已治疗的乳腺癌患者为研究对象,以2021年6月至2022年5月化疗的乳腺癌患者为常规护理组(n=58),2022年6月至2023年6月化疗的乳腺癌患者为局部冷敷法组(n=55)。比较两组在4次PLD化疗阶段HFS的发生率、患者治疗依从性、诊疗满意度及患者就医体验感。结果 局部冷敷法组HFS发生率为23.6%(13/55),常规护理组为44.8%(26/58);局部冷敷法组HFS发生率低于常规护理组(χ^(2)=5.609,P=0.018)。局部冷敷法组HFS严重程度轻于对照组(P<0.05)。局部冷敷法组Ⅱ级及以上HFS发生率为10.9%、常规护理组为25.9%;局部冷敷法组Ⅱ级及以上HFS发生率低于常规护理组(P<0.05)。局部冷敷法组治疗依从性及满意度均高于常规护理组(P<0.05)。结论 局部冷敷法可有效预防和降低PLD化疗过程中HFS的发生率和严重程度、提高患者护理干预的依从性、患者满意度较高。Objective To observe the application effect of local cold compress in pegylated liposomal doxorubicin(PLD)induced hand-foot syndrome(HFS)from a clinical perspective.Methods During June 2021 to June 2023,a non-synchronous randomized controlled trial was conducted to recruit breast cancer(BC)patients who received chemotherapy with a PLD in the Department of Breast Surgery,Affiliated Hospital of Hebei Engineering University as the research objects,they were randomized to the routine care group(from June 2021 to May 2022,n=58)or local cold compress group(from June 2022 to June 2023,n=55).The incidence of HFS,treatment compliance,satisfaction and medical experience of the patients were included as comparisons between groups.Results The incidence of HFS in the local cold compress group was significantly lower than that of the routine care group(23.6%[13/55]vs 44.8%[26/58],χ^(2)=5.609,P=0.018).The severity of HFS in the local cold compress group was significantly lighter than that of the routine care group(P<0.05).The incidence of HFS of grade Ⅱ and above in the local cold compress group was significantly lower than that of the routine care group(10.9%vs 25.9%,P<0.05).The treatment compliance and satisfaction of patients in the local cold compress group were significantly higher than those of the routine care group(P<0.05).Conclusion Local cold compress can effectively prevent the incidence and reduce and severity of HFS in chemotherapy with a PLD,and it is capable of improving the treatment compliance and satisfaction of patients.

关 键 词：手足口病 局部冷敷 乳腺癌 盐酸多柔比星脂质体 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]