精子染色质完整性对功能的影响及其检测方法研究进展  

Research progress on the effect of sperm chromatin integrity on function and its detection methods

作　　者：刘岱缘 张朝晖 康现江[3] Daiyuan Liu;Zhaohui Zhang;Xianjiang Kang(Department of Reproduction Medicine,Baoding No.1 Central Hospital,Baoding 071000,China;Graduate School,Hebei Medical University,Shijiazhuang 050017,China;College of Life Science,Hebei University,Baoding 071000,China)

机构地区：[1]保定市第一中心医院生殖医学科,保定071000 [2]河北医科大学研究生学院,石家庄050017 [3]河北大学生命科学学院,保定071000

出　　处：《遗传》2024年第7期511-529,共19页Hereditas（Beijing)

基　　金：保定市科技计划项目(编号:2341ZF280);保定市第一中心医院博士基金资助。

摘　　要：精子染色质不仅携带父系DNA等遗传信息,还携带有结构蛋白、表观遗传信息、高级染色质结构(如基质附着区和端粒)等众多信息,这些信息在胚胎发育过程中均发挥着重要作用。本文主要综述了精子染色质携带的这些不同信息对精子功能和胚胎发育的影响及其相关检测方法的研究进展,以期为临床不育、胚胎停育和反复流产的病因筛查提供理论依据和科学的诊疗策略,改善自然受孕和辅助生殖助孕的妊娠结局。Sperm chromatin not only carries genetic information such as paternal DNA,but also carries structural proteins,epigenetic information,and higher-order chromatin structures(such as matrix attachment regions and telomeres),etc.These information play an important role in embryonic development.This article mainly reviews the effects of these different information carried by sperm chromatin on sperm function and embryonic development and the research progress of related detection methods,in order to provide a theoretical basis and scientific diagnosis and treatment strategies for the etiology screening of clinical infertility,embryo arrest and recurrent miscarriage,so as to improve the pregnancy outcomes of natural conception and assisted reproduction.

关 键 词：精子染色质 表观遗传学 精子DNA损伤 精子功能 染色质高级结构 

分 类 号：R339.21[医药卫生—人体生理学]