托法替布治疗甲扁平苔藓一例  

Nail lichen planus treated with tofacitinib:a case report

作　　者：薛晓彤 赵晴 曹珊 刘永霞 周桂芝[1,2] 张福仁 XUE Xiaotong;ZHAO Qing;CAO Shan;LIU Yongxia;ZHOU Guizhi;ZHANG Furen(Hospital for Skin Diseases,Shandong First Medical University,Jinan 250022,China;Shandong Provincial Institute of Dermatology and Venereology,Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院,山东济南250022 [2]山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2024年第8期576-577,共2页China Journal of Leprosy and Skin Diseases

基　　金：山东省重点研发计划(重大科技创新工程)项目(编号:2021LCZX07);中国博士后科学基金第74批面上资助(编号:2023M742162)。

摘　　要：甲扁平苔藓发病机制不清,尚缺乏明确的用药指导方案,既往报道糖皮质激素、阿维A、免疫抑制剂(如甲氨蝶呤、环孢素、吗替麦考酚酯)、生物制剂(如依那西普)、氨苯砜等对治疗甲扁平苔藓有一定疗效,但大部分只能缓解。近期有研究发现JAK/STAT信号通路在甲扁平苔藓致病中可能发挥重要作用,且已有4例JAK抑制剂治疗相关报道。本文报道1例使用JAK抑制剂枸橼酸托法替布缓释片治疗甲扁平苔藓的患者,4个月后部分甲损害改善,见新甲生长,目前随访中。The pathogenesis of nail lichen planus is unclear,and lack of clear drug guidance.It has been reported that glucocorticoids,avitamin A,immunosuppressants(such as methotrexate,cyclosporine,morpheolate),biologics(such as etanercept),and sulfoxone have certain effects on the treatment of lichenus planus,but most of them can only alleviate.Recent studies have found that the JAK/STAT signaling pathway may play an important role in the pathogenesis of nail lichen planus,and 4 cases of JAK inhibitor treatment have been reported.This paper reports a case which the JAK inhibitor tofacitinib citrate sustained release tablets were used to treat onychlichen planus.After 4 months,partial onychia damage was improved and new nail growth was observed.

关 键 词：甲扁平苔藓 托法替布 

分 类 号：R758.65[医药卫生—皮肤病学与性病学]