四种杯状病毒调控宿主免疫类细胞因子表达的研究进展  

Research Progress of Regulating Immune Cytokine Expression in Responses to Four Caliciviruses

作　　者：杨洪早 朱杰[1] 缪秋红[1] 汤傲星 陈少宇 袁莉刚[2] 刘光清[1] YANG Hongzao;ZHU Jie;MIAO Qiuhong;TANG Aoxing;CHEN Shaoyu;YUAN Ligang;LIU Guangqing(Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China;College of Veterinary Medicine,Gansu Agricultural University,Lanzhou 730070,China)

机构地区：[1]中国农业科学院上海兽医研究所,上海200241 [2]甘肃农业大学动物医学院,兰州730070

出　　处：《中国动物传染病学报》2024年第3期183-192,共10页Chinese Journal of Animal Infectious Diseases

基　　金：国家自然科学基金项目(32000109);国家自然科学基金项目(32172832);上海市扬帆计划项目(20YF1457700)。

摘　　要：杯状病毒科(Caliciviridae)为无囊膜的单股正链RNA病毒,包含许多对人类和动物健康带来严重威胁的病毒成员。由于该病毒科的大部分成员均不能在体外进行有效增殖,导致杯状病毒的研究相对滞后,虽然已取得了一些重要的进展,但还存在诸多问题亟待解决。基于此,本文综述了目前已证实的人诺如病毒(HuNoV)、鼠诺如病毒(MNV)、猫杯状病毒(FCV)和兔出血症病毒(RHDV)四种常见杯状病毒感染机体后干扰素、白介素、肿瘤坏死因子等免疫类细胞因子的表达水平及其作用机制,以了解免疫类细胞因子与杯状病毒感染的关系。为探讨病毒与宿主免疫系统之间的相互作用机制提供新思路。The Caliciviridae family is a non-enveloped,single-stranded positive-stranded RNA virus,which contains many virus members that pose a serious threat to human and animal health.Difficulty in virus growth retarded research of caliciviruses.Although calicivirus studies have achieved great progress,there are stills many questions that remain to be resolved.In this review,we summarized the current evidence on the interactions of several cytokines within caliciviruses,including interferons,interleukins,and TNF-α,and their regulatory mechanisms following infection with HuNoV,MNV,FCV and RHDV,to understand the relationship between cytokines and virus infection.This article provided new ideas for understanding the relationship between immune cytokines and calicivirus infection and exploring the mechanism of interaction between the virus and host immune system.

关 键 词：人诺如病毒 鼠诺如病毒 猫杯状病毒 兔出血症病毒 免疫类细胞因子 作用机制 

分 类 号：S852.4[农业科学—基础兽医学]