“miRNA-肠道微生物群”功能轴对骨质疏松症的影响机制  

Exploration of the mechanism of osteoporosis based on the functional axis of miRNA-intestinal microbiota

作　　者：胡丹[1] 杨欣 李娟[2] 张浩令 HU Dan;YANG Xin;LI Juan;ZHANG Haoling(Department of Nursing,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016;Academic Affairs Office,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Institute of Advanced Medicine and Dentistry,Universiti Sains Malaysia,Penang 13200,Malaysia)

机构地区：[1]重庆医科大学附属第一医院护理部,重庆400016 [2]重庆医科大学附属第一医院教务处,重庆400016 [3]马来西亚理科大学高级医学和牙科研究所,马来西亚槟城13200

出　　处：《中国骨质疏松杂志》2024年第7期1067-1072,共6页Chinese Journal of Osteoporosis

基　　金：甘肃省教育科技创新项目(2022A-067);甘肃省高等学校创新基金(2023A-088);甘肃省自然科学基金(22JR5RA582);甘肃省科技计划项目重点研发计划国际科技合作类(23YFWA0005);重庆医科大学未来医学青年创新团队支持计划(W0019)。

摘　　要：骨质疏松症(osteoporosis, OP)是一种以骨质减少、骨微结构破坏为特征的系统性骨病,其发病机制涉及遗传、环境和生物多种因素的相互作用。近年来,微小RNA(miRNA)与肠道微生物群(gut microbiota, GM)在其中的影响越来越引人关注。miRNA通过调控成骨细胞介导的骨形成和破骨细胞介导的骨吸收干预OP的进程,而GM则通过调节免疫反应、代谢功能、激素平衡等多重途径影响骨代谢。笔者旨在深入剖析“miRNA-肠道微生物群”功能轴对OP的作用机制,为OP的预防和治疗提供参考依据。Osteoporosis,a systemic bone disease characterized by bone loss and destruction of bone microstructure,is driven by a complex interplay of genetic,environmental,and biological factors.Recently,miRNA and intestinal microbiota have emerged as key factors in the pathogenesis of osteoporosis,garnering increasing attention.Specifically,miRNA influences osteoporosis development by modulating osteoblast-mediated bone formation and osteoclast-mediated bone resorption,while intestinal microbiota impacts bone metabolism through the regulation of immune response,metabolic function,hormone balance,and other complex pathways.This article aims to analyze the functional axis of the miRNA-intestinal microbiota in osteoporosis,shedding light on its mechanism and providing valuable insights for the prevention and treatment of osteoporosis.

关 键 词：MIRNA 肠道微生物群 骨质疏松症 骨代谢 

分 类 号：R589.5[医药卫生—内分泌]