HMGB1-TLR4-IL-23-IL-17A轴在寻常型银屑病患者血清中的表达水平及临床意义  

Expression level and clinical significance of HMGB1-TLR4-IL-23-IL-17A axis in serum of patients with psoriasis vulgaris

作　　者：朱小凤 林雅雯 窦越 王静[1] 胡海友[1] 高昱[1] 马蕾[1] ZHU Xiaofeng;LIN Yawen;DOU Yue;WANG Jing;HU Haiyou;GAO Yu;MA Lei(Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院,滨州256603

出　　处：《中国免疫学杂志》2024年第7期1479-1483,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金青年科学基金项目(81803145);山东省自然科学基金(ZR2023MH311)。

摘　　要：目的:探讨HMGB1-TLR4-IL-23-IL-17A轴在寻常型银屑病患者血清中的表达水平及临床意义。方法:采用ELISA检测60例中重度寻常型银屑病患者和30例健康志愿者血清中HMGB1、TLR4、IL-23、IL-17A的表达水平,比较各细胞因子表达差异及其与疾病严重程度评分(PASI)的相关性。检测并比较IL-17A抑制剂诱导期治疗后皮损改善率达PASI75及以上的22例中重度寻常型银屑病患者血清HMGB1-TLR4-IL-23-IL-17A轴表达水平的变化。结果:寻常型银屑病患者血清HMGB1、TLR4、IL-23、IL-17A表达水平显著高于健康对照组,重度患者表达水平高于中度患者,并与PASI评分呈正相关。IL-17A抑制剂诱导期后,银屑病患者血清中HMGB1-TLR4-IL-23-IL-17A轴表达水平显著降低。结论:寻常型银屑病患者血清中HMGB1-TLR4-IL-23-IL-17A轴高表达,且与疾病严重程度相关,该信号轴参与了寻常型银屑病的疾病过程,为银屑病免疫治疗提供了新的思路。Objective:To investigate the expression level and clinical significance of HMGB1-TLR4-IL-23-IL-17A axis in serum of patients with psoriasis vulgaris.Methods:The expression levels of HMGB1,TLR4,IL-23 and IL-17A in serum of 60 patients with psoriasis vulgaris and 30 healthy volunteers were detected by ELISA.In addition,the differences of cytokines expression levels between moderate and severe psoriasis patients were compared,and the correlation between the expression levels of cytokines and the disease severity expressed by psoriasis area and severity index(PASI)were analyzed.The differences of expression levels of HMGB1-TLR4-IL-23-IL-17A axis before and after IL-17A inhibitor induction treatment were detected and compared in 22 moderate to severe psoriasis patients reached PASI75 and higher level.Results:The expression levels of serum HMGB1,TLR4,IL-23 and IL-17A in patients with psoriasis were obviously higher than those of healthy controls.Moreover,the expression levels of serum HMGB1,TLR4,IL-23 and IL-17A were even elevated in severe patients compared with moderate patients,and were positively correlated with PASI score.After induction treatment of IL-17A inhibitor,the expression levels of HMGB1-TLR4-IL-23-IL-17A aixs decreased significantly in serum of patients with psoriasis.Conclusion:HMGB1-TLR4-IL-23-IL-17A axis is highly expressed in patients with psoriasis vulgaris,and positively related to the disease severity,which may be involved in the disease process of psoriasis vulgaris and provide a new idea for the immunotherapy of psoriasis.

关 键 词：银屑病 HMGB1 TLR4 IL-23 IL-17A 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]