柯里拉京在肝炎、肝纤维化和肝癌中的作用及机制研究进展  

Advances in role and mechanism of corilagin in hepatitis,liver fibrosis and hepatic carcinoma

作　　者：刘新羽 史晓睿 张惠 闫风连 LIU Xinyu;SHI Xiaorui;ZHANG Hui;YAN Fenglian(Institute of Immunology and Molecular Medicine,Basic Medical College,Jining Medical University,Jining 272067,China)

机构地区：[1]济宁医学院基础医学院免疫学与分子医学研究所,济宁272067

出　　处：《中国免疫学杂志》2024年第7期1548-1552,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金面上项目(82171810);山东省医药卫生科技发展计划项目(202002070949);山东省大学生创新训练计划项目(S202110443039);国家级大学生创新训练计划项目(S202010443005)。

摘　　要：柯里拉京是多种中药的主要活性成分,具有广泛的药理作用,在肝炎、肝纤维化和肝癌等多种肝脏疾病中均具有保护作用,因此在治疗肝脏相关疾病方面显示出广阔的应用前景,但应用过程中暴露的问题促使研究者进一步探索柯里拉京的潜在作用。本文总结了近年柯里拉京在肝炎、肝纤维化和肝癌中的作用及机制研究进展,以期为后续研究和应用提供参考。Corilagin is one of major bioactive compounds in many Chinese medical plants,which has been demonstrated to exhibit multiple pharmacological activities.Hepatoprotective effects of corilagin have been reported in some liver diseases,such as hepatitis,liver fibrosis and hepatic carcinoma.Therefore,corilagin has shown broad prospects in treatment of liver diseases.However,problems exposed in application process prompted researchers to further explore potential role of corilagin.Research progress of the role and mechanism of corilagin in hepatitis,liver fibrosis and hepatic carcinoma are summarized to provide reference for subsequent studies.

关 键 词：肝脏疾病 柯里拉京 肝炎 肝纤维化 肝癌 机制 

分 类 号：R392.12[医药卫生—免疫学]