高通量TCR免疫组库技术在艾滋病中的应用及前景分析  

Application and prospect analysis of high-throughput TCR immune repertoire technology in AIDS

作　　者：任莹珂 李杰[2] 许前磊[2] 李强[2] 王露[1] 桑锋[2] REN Yingke;LI Jie;XU Qianlei;LI Qiang;WANG Lu;SANG Feng(Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of the Henan University of Traditional Chinese Medicine,Henan Key Laboratory of Viral Diseases Prevention and Treatment of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,郑州450000 [2]河南中医药大学第一附属医院,河南省病毒性疾病中医药防治重点实验室,郑州450000

出　　处：《中国免疫学杂志》2024年第7期1565-1568,F0003,共5页Chinese Journal of Immunology

基　　金：河南省科技攻关项目(212102311126);河南省中医药科学研究专项课题(20-21ZY2101,2022ZY2012);河南省高等学校重点科研项目(21A360010);河南省病毒性疾病中医药防治重点实验室开放基金课题(SBDSYY2020-001,SBDSYY2020-002);河南省特色骨干学科中医学学科建设项目(STG-ZYXKY-2020029);河南省科技攻关课题(202102310503)。

摘　　要：T细胞受体(TCR)免疫组库是机体所有TCR的总和,TCR免疫组库的多样性与HIV识别和免疫逃逸密切相关。高通量免疫组库测序技术能够检测分析TCR组库的所有序列,真实反映所有TCR的遗传信息,全面揭示TCR组库的复杂性和多样性。通过高通量测序技术分析TCR免疫组库变化可监测HIV患者诊疗情况、疾病进展及预后,同时有助于疫苗研发、病毒库清除及临床疗效评价,从而为丰富HIV/AIDS防治思路和靶点提供依据。T cell receptors(TCR)immune repertoire is sum of all TCR in body,and diversity of TCR immune repertoire is closely related to HIV recognition and immune escape.High-throughput immune repertoire sequencing technology is able to detect and analyze all sequences of TCR immune repertoire,truly reflect genetic information of all TCR,and comprehensively reveal complexity and diversity of TCR immune repertoire.Analysis of changes in TCR immune group database of HIV patients through high-throughput sequencing technology can monitor their diagnosis and treatment,disease progression and prognosis,and can also contribute to vaccine development,latent reservoir clearance and clinical efficacy evaluation,so as to provide a theoretical basis for enriching prevention and treatment ideas and targets of HIV/AIDS.

关 键 词：高通量TCR免疫组库技术 HIV AIDS 

分 类 号：R512.91[医药卫生—内科学]