2D-LC/MS技术在中药分析中的应用  

Application of two-dimensional liquid chromatography combined with high resolution mass spectrometry in the analysis and identification of traditional Chinese medicine components

作　　者：侯晓燕 周利[2] 李翔 康利平[2] 刘二伟[1,3] HOU Xiao-yan;ZHOU Li;LI Xiang;KANG Li-ping;LIU Er-wei(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;State Key Laboratory of Component Chinese Medicine of Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学,天津301617 [2]道地药材品质保障与资源持续利用全国重点实验室,中国中医科学院中药资源中心,北京100700 [3]天津中医药大学组分中药国家重点实验室,天津301617

出　　处：《化学工程师》2024年第7期64-68,共5页Chemical Engineer

基　　金：中央级公益性科研院所基本科研业务费专项基金(ZZ15-WT-04);名贵中药资源可持续利用能力建设项目(2060302-2205-03);中国中医科学院科技创新工程项目(CI2023E002,CI2021A05206,CI2021A04007)。

摘　　要：2D-LC/MS技术具有强大的分离能力和分辨率,且分析速度快、灵敏度高,能够提供化合物的精确质量数及碎片结构信息,可有效解决中药复杂体系中共洗脱及微量成分无法表征鉴定的问题,在中药分析领域具有良好的应用前景。本文简要综述了2D-LC/MS技术的特点及其在中药化学成分分析和鉴定中的应用,为今后2D-LC/MS技术在中药研究中发挥更大的作用提供参考。Two-dimensional liquid chromatography technology has strong separation ability and peak capacity,and high sensitivity of high-resolution mass spectrometry,which can provide accurate mass number and fragment structure information of compounds.It can effectively solve the problems of co-elution and trace components can not be characterized and identified in complex systems of traditional Chinese medicine.It has good application prospects in the field of traditional Chinese medicine analysis.This paper briefly summarizes the characteristics of 2D-LC/MS technology and its application in the analysis and identification of chemical components of traditional Chinese medicine,so as to provide reference for 2D-LC/MS technology to play a greater role in the research of traditional Chinese medicine in the future.

关 键 词：二维液相色谱 高分辨质谱 在线二维 中药化学成分 表征鉴定 

分 类 号：R9[医药卫生—药学]