Mechanically strong porous bioceramic tubes facilitate large segmental bone defect repair by providing long-term structurally stability and promoting osteogenesis  

作　　者：Lijun Xie Jiahao Zhang Hangxiang Sun Zehao Chen Wangsiyuan Teng Xupeng Chai Cong Wang Xianyan Yang Yifan Li Sanzhong Xu Zhongru Gou Zhaoming Ye 

机构地区：[1]Department of Orthopedic Surgery,the Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310000,PR China [2]Orthopedics Research Institute of Zhejiang University,Hangzhou 310000,PR China [3]Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province,Hangzhou 310000,PR China [4]Bio-nanomaterials and Regenerative Medicine Research Division,Zhejiang-California International Nanosystem Institute,Zhejiang University,Hangzhou 310058,PR China [5]Department of Orthopedics,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,PR China

出　　处：《Engineered Regeneration》2024年第1期1-10,共10页再生工程（英文）

基　　金：support from the Medical Science and Technology Project of Zhejiang Province (2022+ZDXK-04);Zhejiang Provincial Basic Research for Public Welfare Funds (LGF20H060016,LGF21H060006,LGF22E030002);National Natural Science Foundation of China (82172419,82101649);Zheiang Provincial Natural Science Foundation of China (LZ22E020002).

摘　　要：Mechanically strong magnesium-doped Ca-silicate bioceramic scaffolds have many advantages in repairing large segmental bone defects.Herein we combine β-TCP with 6 mol%magnesium-doped calcium silicate(Mg6)at three different ratios(TCP,TCP+15%Mg6,TCP+85%Mg6)to find an appropriate ratio which can exert considerable influence on bone regeneration.In this study,the bioceramic scaffolds were assessed for mechanical strength,bioactive ion release,biocompatibility,and osteogenic capacity through in vitro testing.Additionally,the potential for promoting bone regeneration was investigated through in vivo implantation of porous tube-like scaffolds.The results showed that the compressive strength increased with the augmentation of Mg6 component.Especially the compressive strength of the TCP+85%Mg6 group reached 38.1±3.8 MPa,three times that of the other two groups.Furthermore,extensive in vivo investigations revealed that the TCP+85%Mg6 bioceramic scaffolds were particularly beneficial for the osteogenic capacity of critical-sized femoral defects(20 mm in length).Altogether,magnesium doping in bioceramic implants is a promising strategy to provide stronger mechanical support and enhance osteogenesis to accelerate the repair of large defects.

关 键 词：Bioceramic tubes Mg-doped calcium silicate Porous structural stability Large segmental bone defects Digital light processing 

分 类 号：R318[医药卫生—生物医学工程]