Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering  

作　　者：Zahid Hussain Shah Mehmood Xingzhu Liu Yuanshan Liu Guocheng Wang Renjun Pei 

机构地区：[1]School of Nano-Tech and Nano-Bionics,University of Science and Technology of China(USTC),Hefei 230026,PR China [2]CAS Key Laboratory for Nano-Bio Interface,Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO),Chinese Academy of Sciences,Suzhou 215123,PR China [3]Research Center for Human Tissues and Organs Degeneration,Shenzhen Institute of Advanced Technology(SIAT),Chinese Academy of Science,Shenzhen 518055,PR China

出　　处：《Engineered Regeneration》2024年第1期21-44,共24页再生工程（英文）

基　　金：supported by National Natural Science Foundation of China (31971326);Science and Technology Project of Suzhou (ZXT2022007).

摘　　要：Bone fractures are common occurrence in clinical settings,creating a high demand for effective repair material.Unfortunately,limited graft availability,donor site morbidities,unpredictable clinical outcomes,immunologic reactions,infection risks,and geometrical mismatching concerns hampered tissue graft use and underscored the need for scaffolds for more effective bone reconstructions due to their tunable properties.Significant progress has been carried out in past decade in the fields of nanoceramics synthesis,bioconjugate chemistry,and composite material processing.This review outlines hierarchical structures and biology of bone tissue,materialistic compo-nents of scaffolds(bioceramics,polymers,bioactive drugs),featured scaffolding strategies(nanofibers,hydrogels,aerogels,bioprinting,and fiber-reinforced composite),and emphasis that hierarchical and physiochemical char-acteristics of bone should be used as an inspiration for scaffold design.This review discussed how differences in materiobiological aspects of scaffolds,such as polymer/bioceramic nanocomposite,mineralized nanocomposite,matrix-rich nanocomposite,3D microenvironmental cues,pore space cues,mechanical cues,usage of physical stimulation(magnetic,electroactive,and photoactivated cues),surface cues(wettability,roughness,textured,and surface charge),and biointerface cues(cell-biomaterial interactions,cell-selective homing,and cell regula-tory strategies)modulate cellular and biological response for bone tissue engineering.This study further outlines the challenges and benefits of integrating materiobiological cues of scaffolds for bone tissue engineering.

关 键 词：Bone substitute Scaffolds MINERALIZATION Materiobiology Bone tissue engineering 

分 类 号：R318[医药卫生—生物医学工程]