Research Progress in Enantioselective Radical Desymmetrization Reactions  

作　　者：Chang-Jiang Yang Lin Liu Qiang-Shuai Gu Xin-Yuan Liu 

机构地区：[1]Department of Chemistry and Dongguan Key Laboratory for Data Science and Intelligent Medicine,Great Bay University,Dongguan 523000 [2]Shenzhen Grubbs Institute,Department of Chemistry,and Guangming Advanced Research Institute,Southern University of Science and Technology,Shenzhen 518055 [3]Academy for Advanced Interdisciplinary Studies and Department of Chemistry,Southern University of Science and Technology,Shenzhen 518055

出　　处：《CCS Chemistry》2024年第7期1612-1627,共16页中国化学会会刊（英文）

基　　金：Financial support from the National Natural Science Foundation of China (grant nos.22025103,92256301,21831002,22271133,22101122,and 22201127);the National Key R&D Program of China (grant nos.2021YFF0701604 and 2021YFF0701704);New Cornerstone Science Foundation through the XPLORER PRIZE,Shenzhen Science and Technology Program (grant nos.KQTD20210811090112004 and JCYJ20220818100600001);Shenzhen Key Laboratory of Cross-Coupling Reactions (grant no.ZDSYS20220328104200001).

摘　　要：Enantioselective radical desymmetrization is a highly effective approach for rapidly creating enantioenriched molecules,introducing dramatically increased structural complexity from readily available prochiral or meso compound feedstocks.Two strategic modes have been developed for these reactions,which differ in the nature of the stereo-determining steps.The first category deals primarily with the stereoselective desymmetrization of closed-shell radical precursors or functional reagents,whereas the second category achieves desymmetrization by stereoselectively functionalizing open-shell radical species.This mini-review explores the research progress in this growing field,aiming to elucidate mechanistic scenarios related to stereochemical control.Additionally,it offers insights into the challenges and opportunities that lie ahead for further development.

关 键 词：radical desymmetrization enantioselective desymmetrization radical functionalization transition metal catalysis asymmetric catalysis 

分 类 号：O62[理学—有机化学]