Iridium-Catalyzed Asymmetric Hydrogenation of Dialkyl Imines  

作　　者：Zheng Wang Xin-Yi Yang Yue Xu Qi-Lin Zhou 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Frontiers Science Center for New Organic Matter,Nankai University,Tianjin 300071

出　　处：《CCS Chemistry》2024年第4期905-911,共7页中国化学会会刊（英文）

基　　金：supported by the National Key R&D Program of China(grant no.2022YFA1504302);the National Natural Science Foundation of China(grant nos.22188101,91956000,and 92256301);the Fundamental Research Funds for the Central Universities,and the Haihe Laboratory of Sustainable Chemical Transformations.

摘　　要：Asymmetric hydrogenation of dialkyl imines to chiral amines is difficult because the two alkyls of imines are so similar in spatial and electronic structure that chiral catalysts are difficult to distinguish between them.In this study,we described an asymmetric hydrogenation of dialkyl imines by a chiral iridium catalyst containing spiro phosphine-amine-phosphine ligand.By precisely adjusting the chiral pocket of catalyst,a highly efficient catalyst was developed.Using this catalyst,a variety of dialkyl imines were hydrogenated to chiral amines with high yield and enantioselectivity.

关 键 词：spiro PNP ligand iridium catalyst enantioselective hydrogenation dialkyl imines chiral amines 

分 类 号：O62[理学—有机化学]