Recent Advances in Cobalt-Catalyzed Regio-or Stereoselective Hydrofunctionalization of Alkenes and Alkynes  

作　　者：Yan Li Xi Lu Yao Fu 

机构地区：[1]Hefei National Research Center for Physical Sciences at the Microscale,CAS Key Laboratory of Urban Pollutant Conversion,Anhui Province Key Laboratory of Biomass Clean Energy,University of Science and Technology of China,Hefei 230026 [2]Key Laboratory of Precision and Intelligent Chemistry,Department of Applied Chemistry,School of Chemistry and Materials Science,University of Science and Technology of China,Hefei 230026

出　　处：《CCS Chemistry》2024年第5期1130-1156,共27页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(grant nos.22293011 and 22371273);the Youth Innovation Promotion Association of the Chinese Academy of Sciences(grant no.2023476);the National Science Foundation of Anhui Province(grant no.2208085J26);the China Postdoctoral Science Foundation(grant no.BX20230344);the New Cornerstone Science Foundation through the XPLORER PRIZE.

摘　　要：Hydrofunctionalization of alkenes and alkynes is increasingly important in preparing and modifying carbon-centered organic molecules such as pharmaceuticals,agrochemicals,andmaterial precursors.The development of transition-metal-catalysts has revolutionized the hydrofunctionalization of unsaturated hydrocarbons,greatly improving the synthetic efficiency and selectivity of these reactions.In recent years,notable progress has been achieved in low-cost metal-catalyzed alkene and alkyne hydrofunctionalization reactions following the utilization of traditional precious metal catalysts,including palladium,platinum,and rhodium.Earth-abundant cobalt catalysts,which are low in toxicity and exhibit unique reactivity and selectivity,are widely implemented in academic and industrial research.In this review,we highlight recent examples of cobalt-catalyzed hydrofunctionalization of alkenes and alkynes to provide an overview of hydrofunctionalization methods,particularly hydroalkylation reactions.Hydroalkylation reactions greatly expand the scope and utility of cobalt-catalyzed couplings of carbon—carbon bonds.We also highlight the mechanistic considerations and selective determinants involved.We hope our discussion will be informative for future developments in cobalt catalysis and hydrofunctionalization reactions.

关 键 词：hydrofunctionalization cobalt-catalysis ALKENE ALKYNE regioselectivity STEREOSELECTIVITY 

分 类 号：O62[理学—有机化学]