The exploration of cell population data in clinical use: Beyond infectious diseases  

作　　者：Shayuanzi Huang Yin Liu Liu Qian Juan Zhou Dong Wang 

机构地区：[1]Department of Laboratory Medicine,the First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,Guangdong,China [2]Department of Laboratory Medicine,Guangxi Hospital Division of the First Affiliated Hospital,Sun Yat-Sen University,Nanning,Guangxi,China [3]Department of Medical Affair,Danaher Diagnostic Platform,Shanghai,China [4]Department of Oncology,General Hospital of the Southern Theatre Command,PLA,Guangzhou,Guangdong,China

出　　处：《iLABMED》2024年第2期125-140,共16页智能检验医学（英文）

基　　金：the basic and applied basic research projects of Guangdong Province,Grant/Award Number:2021A1515220040。

摘　　要：Cell population data(CPD)is regarded as the fingerprint of a blood cell at a given moment.CPD parameters harbor information associated with cell morphology and can be automatically generated using modern hematological analyzers.Various studies have revealed many unique clinical applications for CPD,especially for infectious diseases,such as sepsis.For example,one monocyte-related CPD parameter is the monocyte distribution width(MDW),which can be generated using a Beckman Coulter hematological analyzer.MDW has received FDA and CE approval for aiding in sepsis diagnosis in adult patients in the emergency department.Additionally,MDW can serve as a diagnostic biomarker in patients infected with SARS-CoV-2.CPD has also been widely explored for possible clinical applications beyond infectious dis-eases,such as for predicting myelodysplastic syndromes,screening for he-matological malignancies,and detecting sterile inflammation.CPD parameter measurements are easily obtained and quite cost-effective,making them practical for clinical use.However,there are some potential drawbacks of CPD parameters.Some pre-analytical conditions can affect CPD values.Further-more,CPD are specific to certain hematological analyzers and the result cannot be transferred between different analyzers.The practical usefulness of CPD reference intervals is also still questionable.In this review,wesummarize the current studies related to CPD and its clinical applications.Additional well-designed clinical studies related to CPD are still expected.

关 键 词：cell population data Coulter principle hematology analyzer infectious diseases white blood cell 

分 类 号：R446[医药卫生—诊断学]