双水平气道正压通气联合甲强龙治疗慢性阻塞性肺疾病急性加重期合并呼吸衰竭效果观察  

Effect of Bilevel Positive Airway Pressure Ventilation Combined with Methylprednisolone in The Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Respiratory Failure

作　　者：叶文浪 Ye Wenlang(Meizhou Second Hospital of Traditional Chinese Medicine,Guangdong Meizhou 514011)

机构地区：[1]梅州市第二中医医院,广东梅州514011

出　　处：《哈尔滨医药》2024年第3期5-8,共4页Harbin Medical Journal

摘　　要：目的探讨双水平气道正压通气(BiPAP)联合甲强龙治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并呼吸衰竭患者效果;方法选取72例AECOPD并呼吸衰竭患者分为两组,对照组给予BiPAP治疗,观察组联合甲强龙治疗,比较临床疗效,呼吸功能、肺功能、血气水平、炎症因子水平;结果观察组疗效总有效率显著高于对照组(P<0.05),治疗前两组患者RR、HR、MAP、PaO_(2)、PaCO_(2)、SaO_(2)、FEV1、FVC、FEV1/FVC、PCT、CRP指标水平差异无统计学意义(P>0.05),治疗后两组患者RR、HR、MAP、PaO_(2)、PaCO_(2)、SaO_(2)、FEV1、FVC、FEV1/FVC、PCT、CRP指标水平均显著改善,且治疗后观察组呼吸功能、肺功能、血气水平、炎症因子水平改善更显著(P<0.05);结论双水平气道正压通气联合甲强龙治疗AECOPD并呼吸衰竭患者可显著提高临床疗效,抑制气道和肺部炎症水平,改善患者肺功能,加速患者康复,值得推广。Objective To investigate the effect of BiPAP combined with methylprednone in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)with respiratory failure.Methods 72 patients with AECOPD combined with respiratory failure admitted were divided into 2 groups.The control group was given BiPAP therapy,and the observation group was combined with methylprednone therapy.The clinical efficacy,respiratory function,lung function,blood gas level and inflammatory factor level were compared.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05),but there were no significant differences in the levels of RR,HR,MAP,PaO_(2),PaCO_(2),SaO_(2),FEV1,FVC,FEV1/FVC,PCT and CRP between the two groups before treatment(P>0.05).After treatment,the levels of RR,HR,MAP,PaO_(2),PaCO_(2),SaO_(2),FEV1,FVC,FEV1/FVC,PCT and CRP in 2 groups were significantly improved.After treatment,RR,HR,MAP,PaO_(2),PaCO_(2),SaO_(2),FEV1,FVC,FEV1/FVC,PCT and CRP in observation group were significantly improved(P<0.05).Conclusion Bilevel positive airway pressure ventilation combined with methylprednone in the treatment of AECOPD patients with respiratory failure can significantly improve clinical efficacy,inhibit airway and lung inflammation levels,improve lung function,and accelerate the recovery of patients,which is worthy of promotion.

关 键 词：双水平气道正压通气 甲强龙 慢性阻塞性肺疾病急性加重期 呼吸衰竭 

分 类 号：R563.8[医药卫生—呼吸系统]