线粒体移植治疗肌少症的潜力  

Potential of mitochondrial transplantation in treatment of sarcopenia

作　　者：李伟[1] 尹洪涛 孙永晨 徐卫娟 孙金玲[1] 金晓东[1] Li Wei;Yin Hongtao;Sun Yongchen;Xu Weijuan;Sun Jinling;Jin Xiaodong(Department of Geriatric Medicine,Zibo Central Hospital,Zibo 255036,Shandong Province,China;Department of Neurology,Zibo Central Hospital,Zibo 255036,Shandong Province,China)

机构地区：[1]淄博市中心医院老年医学科,山东省淄博市255036 [2]淄博市中心医院,神经内科,山东省淄博市255036

出　　处：《中国组织工程研究》2025年第13期2842-2848,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:肌少症是衰老引起的骨骼肌质量和力量下降的一种综合性疾病,是老年人面临的主要健康挑战。越来越多的证据表明,线粒体功能障碍在肌少症的发病机制中起着关键作用。目的:总结线粒体质量控制失调导致肌少症的机制,探讨线粒体移植可能是治疗肌少症的潜在靶点。方法:以“sarcopenia,mitochondrial dysfunction,mitochondrial quality control,mitochondrial transplantation,limitations”和“肌少症,线粒体功能障碍,线粒体质量控制,线粒体移植,局限性”为关键词,检索PubMed和CNKI数据库2009-2023年间相关文献。结果与结论:线粒体功能障碍在肌少症发病机制中发挥关键作用,线粒体移植可能通过改善线粒体生物能量学和调节线粒体相关信号通路成为治疗肌少症的可能策略。虽然部分临床前和临床研究证实线粒体移植治疗各种疾病的潜力,但关于线粒体转移的具体细节方面仍有一些亟待解决的问题。BACKGROUND:Sarcopenia is a comprehensive condition of aging induced decline in skeletal muscle mass and strength and represents a major health challenge for the elderly.Accumulating evidence suggests that mitochondrial dysfunction plays a key role in the pathogenesis of sarcopenia.OBJECTIVE:To summarize the mechanisms by which dysregulation of mitochondrial quality control leads to sarcopenia and to explore whether mitochondrial transplantation may be a potential target for the treatment of sarcopenia.

关 键 词：肌少症 线粒体功能障碍 线粒体质量控制 线粒体移植 局限性 

分 类 号：R459.9[医药卫生—治疗学] R318.06[医药卫生—临床医学] R592