3种熊果苷的安全性评价进展及其化妆品法规管理现状  

Safety evaluation progress of three kinds of arbutin and its current status in cosmetics regulations

作　　者：吴姣娇 章为 王彦超 裴新荣[2] Jiaojiao Wu;Wei Zhang;Yanchao Wang;Xinrong Pei(Hunan Institute for Drug Control,Changsha,Hunan 410001,China;National Institutes for Food and Drug Control,Beijing 100050,China)

机构地区：[1]湖南省药品检验检测研究院,湖南长沙410001 [2]中国食品药品检定研究院,北京100050

出　　处：《日用化学工业（中英文）》2024年第7期853-858,共6页China Surfactant Detergent & Cosmetics

基　　金：湖南省自然科学基金-部门联合基金(2023JJ60108)。

摘　　要：α-熊果苷、β-熊果苷、脱氧熊果苷具有良好的美白作用,但在一定条件下容易产生氢醌,有导致外源性褐黄病、白斑病、致敏、致癌等风险,因此其安全性备受国内外关注。文章通过整理总结近些年欧盟消费者安全科学委员会(SCCS)关于α-熊果苷、β-熊果苷、脱氧熊果苷的安全性评价报告,以及不同国家和地区化妆品法规对熊果苷的监管情况,以期了解熊果苷的安全性评价状况,为我国化妆品中熊果苷的使用及监管提供参考。α-arbutin,β-arbutin and deoxyarbutin have good whitening effect,but they are easy to produce hydroquinone under certain conditions,which has the risk of exogenous ochronosis,achromodermia,sensitization,and carcinogenesis.So their safety has attracted much attention at home and abroad.The author summarizes the safety evaluation reports ofα-arbutin,β-arbutin and deoxyarbutin by the Scientific Committee on Consumer Safety(SCCS)of the European Union in recent years,as well as the supervision situation of cosmetics regulations in different countries and regions,in order to understand the safety evaluation status of arbutin and provide references for the use and supervision of arbutin in cosmetics in China.

关 键 词：熊果苷 安全性评价 美白 化妆品法规 

分 类 号：TQ658[化学工程—精细化工]