Efficacy of budesonide/formoterol inhalation powder in treating viral pneumonia in children  

作　　者：Zi-Liang Lin Xu Xu Jiao-Jiao Yang Li-Qiang Lu Heng Huang Xiao-Zhen Hua Li-Dang Lu 

机构地区：[1]Department of Pediatrics,Cangnan Hospital Affiliated to Wenzhou Medical University,Wenzhou 325800,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第21期4469-4475,共7页世界临床病例杂志

基　　金：the Wenzhou Basic Medical and Health Science and Technology Project,No.Y20210307.

摘　　要：BACKGROUND Respiratory viruses are increasingly detected in children with communityacquired pneumonia.Further strategies to limit antibiotic use in children with viral pneumonia are warranted.AIM To explore clinical efficacy of budesonide/formoterol inhalation powder for viral pneumonia in children and its impact on cellular immunity and inflammatory factor production.METHODS A total of 60 children with viral pneumonia were recruited:30 receiving budesonide/formoterol inhalation powder and 30 conventional symptomatic treatment.Outcome measures included peripheral blood levels of inflammatory cytokines,CD4^(+),CD8^(+),Th1,Th2,Th17 and Treg,clinical efficacy,and incidence of adverse reactions.RESULTS Compared with the control group,the observation group showed a significant reduction in interleukin-6 and high-sensitivity C-reactive protein levels after treatment.Compared with the control group,the observation group showed a significant increase in CD4^(+)/CD8^(+)and Th1/Th2 levels,and a decrease in Th17/Treg levels after treatment.The total effective rates in the observation group and the control group were 93.75%and 85.00%,respectively,which was a significant difference(P=0.003).CONCLUSION Budesonide/formoterol inhalation powder significantly improved therapeutic efficacy for viral pneumonia in children.The mechanism of action may be related to downregulation of the inflammatory response and improved cellular immune function.

关 键 词：Budesonide/Formoterol inhalation powder Viral pneumonia Immunity CD4^(+)/CD8^(+) Th1/Th2 TH17/TREG 

分 类 号：R725.6[医药卫生—儿科]