Relationship of inflammatory indices with left atrial appendage thrombus or spontaneous echo contrast in patients with atrial fibrillation  

作　　者：Zhao Wang Bin-Hao Wang Xiao-Lei Yang Yun-Long Xia Sheng-Min Zhang Ying Che 

机构地区：[1]Department of Ultrasonography,First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning Province,China [2]Arrhythmia Center,First Affiliated Hospital of Ningbo University,Ningbo 315000,Zhejiang Province,China [3]Department of Cardiology,First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning Province,China [4]Department of Ultrasonography,First Affiliated Hospital of Ningbo University,Ningbo 315000,Zhejiang Province,China

出　　处：《World Journal of Clinical Cases》2024年第21期4550-4557,共8页世界临床病例杂志

基　　金：Public Welfare Technology Project of Ningbo Science and Technology Bureau,No.2023S140;Medical Health Science and Technology Project of Zhejiang Province Health Commission,No.2024KY1518.

摘　　要：BACKGROUND Inflammatory indices derived from complete blood tests have been reported to be associated with poor outcomes in patients with atrial fibrillation(AF).The data about the relationship between inflammatory indices and left atrial appendage thrombus(LAAT)or dense spontaneous echo contrast(SEC)are limited.AIM To explore the value of inflammatory indices for predicting the presence of LAAT or dense SEC in nonvalvular AF patients.METHODS A total of 406 patients with nonvalvular AF who underwent transesophageal echocardiography were included and divided into two groups based on the presence(study group)or absence(control group)of LAAT or dense SEC.Inflammatory indices,including the neutrophil-to-lymphocyte ratio(NLR),platelet–tolymphocyte ratio(PLR),and lymphocyte-to-monocyte ratio(LMR),were calculated from complete blood analysis.The associations of inflammatory indices RESULTS LAAT and dense SEC were detected in 11(2.7%)and 42(10.3%)patients,respectively.The PLR only showed an association with LAAT/dense SEC in the univariate model.Elevated NLR(odds ratio[OR]=1.48,95%confidence interval[CI]:1.11-1.98,P=0.007)and reduced LMR(OR=0.59,95%CI:0.41-0.83,P=0.003)were found to be independent risk factors for the presence of LAAT/dense SEC.The areas under the NLR and LMR curves for predicting LAAT/dense SEC were 0.73(95%CI:0.66-0.80,P<0.001)and 0.73(95%CI:0.65-0.81,P<0.001),respectively,while the cutoff values were 2.8(sensitivity:69.8%;specificity:64.0%)and 2.4(sensitivity:71.7%;specificity:60.6%),respectively.CONCLUSION Increased NLR and decreased LMR may predict LAAT/dense SEC in patients with nonvalvular AF.

关 键 词：Nonvalvular atrial fibrillation Left atrial appendage thrombus Spontaneous echo contrast Neutrophil–lymphocyte ratio Lymphocyte–monocyte ratio 

分 类 号：R654.2[医药卫生—外科学]