Exploration of the complex origins of primary constipation  

作　　者：Xing-Lin Zeng Lian-Jun Zhu Xiang-Dong Yang 

机构地区：[1]School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China [2]Colorectal and Anal Surgery,Chengdu Anorectal Hospital,Chengdu 610015,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2024年第24期5476-5482,共7页世界临床病例杂志

摘　　要：Constipation is a common gastrointestinal disorder characterized by infrequentbowel movements and difficulty in passing stools.It can significantly affect anindividual's quality of life and overall well-being.Understanding the causes ofconstipation is important for its effective management and treatment.In thispaper,we have reviewed the primary causes of constipation or functional constipation.Primary constipation is a bowel disorder associated with colonic oranorectal sensorimotor or neuromuscular dysfunction.As per the literature,it ismultifactorial and involves factors such as decreased interstitial cells of Cajal,altered colonic motility,enteric nervous system dysfunction,intestinal flora disturbances,and psychological influences.Clinical symptoms include difficulty indefecation,decreased frequency of defecation,or a feeling of incomplete evacuation.A comprehensive evaluation and management of constipation require aninterdisciplinary approach incorporating dietary modifications,lifestyle changes,pharmacotherapy,and psychological interventions.Further research is imperativeto explain the intricate mechanisms underlying constipation and develop targetedtherapies for improved patient outcomes.

关 键 词：Primary constipation Pathogenesis factors Treatment 

分 类 号：R593.9[医药卫生—内科学]