Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome  

作　　者：Ze-Ning Shi Xin Zhang Chun-Yuan Du Bing Zhao Shu-Gang Liu 

机构地区：[1]Department of Pediatrics,Army Military Medical University Officer School Affiliated Hospital,Shijiazhuang 050000,Hebei Province,China [2]Department of Anesthesiology,Army Military Medical University Officer School Affiliated Hospital,Shijiazhuang 050000,Hebei Province,China [3]Department of Gynecology and Obstetrics,Army Military Medical University Officer School Affiliated Hospital,Shijiazhuang 050000,Hebei Province,China

出　　处：《World Journal of Clinical Cases》2024年第23期5366-5373,共8页世界临床病例杂志

摘　　要：BACKGROUND Neonatal respiratory distress syndrome(NRDS)is one of the most common diseases in neonatal intensive care units,with an incidence rate of about 7%among infants.Additionally,it is a leading cause of neonatal death in hospitals in China.The main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant AIM To explore the effect of pulmonary surfactant(PS)combined with noninvasive positive pressure ventilation on keratin-14(KRT-14)and endothelin-1(ET-1)levels in peripheral blood and the effectiveness in treating NRDS.METHODS Altogether 137 neonates with respiratory distress syndrome treated in our hospital from April 2019 to July 2021 were included.Of these,64 control cases were treated with noninvasive positive pressure ventilation and 73 observation cases were treated with PS combined with noninvasive positive pressure ventilation.The expression of KRT-14 and ET-1 in the two groups was compared.The deaths,complications,and PaO_(2),PaCO_(2),and PaO_(2)/FiO_(2)blood gas indexes in the two groups were compared.Receiver operating characteristic curve(ROC)analysis was used to determine the diagnostic value of KRT-14 and ET-1 in the treatment of NRDS.RESULTS The observation group had a significantly higher effectiveness rate than the control group.There was no significant difference between the two groups in terms of neonatal mortality and adverse reactions,such as bronchial dysplasia,cyanosis,and shortness of breath.After treatment,the levels of PaO_(2)and PaO_(2)/FiO_(2)in both groups were significantly higher than before treatment,while the level of PaCO_(2)was significantly lower.After treatment,the observation group had significantly higher levels of PaO_(2)and PaO_(2)/FiO_(2)than the control group,while PaCO_(2)was notably lower in the observation group.After treatment,the KRT-14 and ET-1 levels in both groups were significantly decreased compared with the pre-treatment levels.The observation group had a reduction of KRT-14 and ET-1 levels than the control group.ROC curve analys

关 键 词：Pulmonary surfactant Non-invasive positive pressure ventilation Neonatal respiratory distress syndrome Keratin-14 ENDOTHELIN-1 

分 类 号：R563.8[医药卫生—呼吸系统] R459.7[医药卫生—内科学]