Rare extraintestinal manifestations of ulcerative colitis treated with dual biologic therapy:A case report  

作　　者：Aleksandra Filipiuk Maciej Gonciarz 

机构地区：[1]Department of Gastroenterology and Internal Medicine,Military Institute of Medicine-National Research Institute in Warsaw,Warsaw 04-141,Poland

出　　处：《World Journal of Clinical Cases》2024年第23期5441-5447,共7页世界临床病例杂志

摘　　要：BACKGROUND Ulcerative colitis(UC)is an idiopathic,chronic inflammatory bowel disease(IBD)most often located in the rectum,but may involve the entire colon.Extra intestinal manifestations(EIMs)occur with varying frequency depending on the affected organ.The most common ones are musculoskeletal EIMs,affecting up to 33%-40%of IBD patients.These include,among others,inflammatory back pain,tendinitis,plantar fasciitis and arthritis.Only a few case reports in literature discuss Achilles tendinitis.CASE SUMMARY This report describes a patient with UC and Achilles tendinitis in whom after many unsuccessful attempts of treatment with sulfasalazine,mesalazine,glucocorticosteroids,infliximab and tofacitinib,a complete UC remission and resolution of Achilles tendinitis were achieved with the use of dual biologic therapy(DBT)-ustekinumab and adalimumab(ADA).CONCLUSION This case mentions rare EIMs of UC and suggests that DBT may be an alternative for patient with ulcerative colitis and EIMs.

关 键 词：Achilles tendinitis Dual biologic therapy Extraintestinal manifestations SPONDYLOARTHROPATHY Ulcerative colitis Case report 

分 类 号：R542.21[医药卫生—心血管疾病]