Omadacycline in the treatment of scrub typhus:Three case reports  

作　　者：Xue-Mei Lang Yun Qiu Ya-Juan Jia Hong Sun Su-Min Gao Hong-Mei Zhao 

机构地区：[1]Department of Emergency Medicine,The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huai’an 223000,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2024年第25期5832-5838,共7页世界临床病例杂志

基　　金：Supported by National Natural Science Foundation of China,No.81800721;the Postdoctoral Foundation of China,2020M671387.

摘　　要：BACKGROUND Scrub typhus is a naturally occurring acute infectious disease that is primarily transmitted through the bites of chiggers or larval mites infected by Orientia tsutsugamushi(O.tsutsugamushi).Omadacycline,a novel tetracycline,exhibits potent antibacterial efficacy against both typical bacteria and atypical pathogens.However,omadacycline application in the treatment of scrub typhus remains limited.CASE SUMMARY In the present work,we report several cases of scrub typhus,with the main clinical symptoms being fever,the formation of eschars or ulcers,local or systemic lymphadenopathy,headache,myalgia and rash.Blood samples were collected before omadacycline was administered,and O.tsutsugamushi infection was confirmed through targeted next-generation sequencing(tNGS).After two days of treatment,the patients’symptoms,including fever,were alleviated,with no adverse drug reactions.CONCLUSION tNGS is an effective method for diagnosing scrub typhus.Omadacycline can be considered an alternative option for antiinfective therapy in patients with O.tsutsugamushi infections.

关 键 词：Omadacycline Scrub typhus Orientia tsutsugamushi Targeted nextgeneration sequencing ESCHAR Case report 

分 类 号：R51[医药卫生—内科学] R96[医药卫生—临床医学]