Risk factors associated with intraoperative persistent hypotension in pancreaticoduodenectomy  

作　　者：Xing-Jun Wang Xi-Chen Xuan Zhao-Chu Sun Shi Shen Fan Yu Na-Na Li Xue-Chun Chu Hui Yin You-Li Hu 

机构地区：[1]Department of Anesthesia and Perioperative Medicine,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第6期1582-1591,共10页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain unclear.AIM To clarify the risk factors associated with IPH during PD,ensuring patient safety in the perioperative period.METHODS A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in PD.These factors included age,gender,body mass index,American Society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas parameters.IPH was defined as sustained mean arterial pressure<65 mmHg,requiring prolonged deoxyepinephrine infusion for>30 min despite additional deoxyepinephrine and fluid treatments.RESULTS Among 1596 PD patients,661(41.42%)experienced IPH.Multivariate logistic regression identified key risk factors:increased age[odds ratio(OR):1.20 per decade,95%confidence interval(CI):1.08-1.33](P<0.001),longer surgery duration(OR:1.15 per additional hour,95%CI:1.05-1.26)(P<0.01),and greater blood loss(OR:1.18 per 250-mL increment,95%CI:1.06-1.32)(P<0.01).A novel finding was the association of arterial blood Ca^(2+)<1.05 mmol/L with IPH(OR:2.03,95%CI:1.65-2.50)(P<0.001).CONCLUSION IPH during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma Ca^(2+).

关 键 词：Risk factors PANCREATICODUODENECTOMY Perioperative period Intraoperative persistent hypotension Retrospective cohort study 

分 类 号：R656.64[医药卫生—外科学]