Unleashing the pathological role of epithelial-to-mesenchymal transition in diabetic nephropathy: The intricate connection with multifaceted mechanism  

作　　者：Pitchai Balakumar 

机构地区：[1]The Office of Research and Development,Periyar Maniammai Institute of Science&Technology(Deemed to be University),Thanjavur 613403,Tamil Nadu,India [2]School of Pharmacy,Faculty of Health and Medical Sciences,Taylor’s University,Subang Jaya 47600,Selangor,Malaysia

出　　处：《World Journal of Nephrology》2024年第2期1-4,共4页世界肾病学杂志（英文版）

摘　　要：Renal epithelial-to-mesenchymal transition(EMT)is a process in which epithelial cells undergo biochemical changes and transform into mesenchymal-like cells,resulting in renal abnormalities,including fibrosis.EMT can cause diabetic neph-ropathy through triggering kidney fibrosis,inflammation,and functional impair-ment.The diverse molecular pathways that drive EMT-mediated renal fibrosis are not utterly known.Targeting key signaling pathways involved in EMT may help ameliorate diabetic nephropathy and improve renal function.In such settings,un-derstanding precisely the complicated signaling networks is critical for develo-ping customized therapies to intervene in EMT-mediated diabetic nephropathy.

关 键 词：Diabetes mellitus Epithelial-to-mesenchymal transition E-CADHERIN N-CADHERIN Renal fibrosis Diabetic nephropathy 

分 类 号：R692[医药卫生—泌尿科学] R587.1[医药卫生—外科学]