Establishment of a nomogram model for predicting therapy complications in patients with polycythemia and deep venous thrombosis  

作　　者：Ming-Xian Zhao Guo-Jie Li 

机构地区：[1]Department of Vascular Surgery,Qinghai Province Cardiovascular and Cerebrovascular Disease Specialist Hospital,Xining 810000,Qinghai Province,China

出　　处：《World Journal of Clinical Cases》2024年第22期4881-4889,共9页世界临床病例杂志

基　　金：Supported by Guiding Project of Qinghai Provincial Health Commission,No.2021-wjzdx-89.

摘　　要：BACKGROUND Patients with deep venous thrombosis(DVT)residing at high altitudes can only rely on anticoagulation therapy,missing the optimal window for surgery or thrombolysis.Concurrently,under these conditions,patient outcomes can be easily complicated by high-altitude polycythemia(HAPC),which increases the difficulty of treatment and the risk of recurrent thrombosis.To prevent reaching this point,effective screening and targeted interventions are crucial.Thus,this study analyzes and provides a reference for the clinical prediction of thrombosis recurrence in patients with lower-extremity DVT combined with HAPC.AIM To apply the nomogram model in the evaluation of complications in patients with HAPC and DVT who underwent anticoagulation therapy.METHODS A total of 123 patients with HAPC complicated by lower-extremity DVT were followed up for 6-12 months and divided into recurrence and non-recurrence groups according to whether they experienced recurrence of lower-extremity DVT.Clinical data and laboratory indices were compared between the groups to determine the influencing factors of thrombosis recurrence in patients with lowerextremity DVT and HAPC.This study aimed to establish and verify the value of a nomogram model for predicting the risk of thrombus recurrence.RESULTS Logistic regression analysis showed that age,immobilization during follow-up,medication compliance,compliance with wearing elastic stockings,and peripheral blood D-dimer and fibrin degradation product levels were indepen-dent risk factors for thrombosis recurrence in patients with HAPC complicated by DVT.A Hosmer-Lemeshow goodness-of-fit test demonstrated that the nomogram model established based on the results of multivariate logistic regression analysis was effective in predicting the risk of thrombosis recurrence in patients with lowerextremity DVT complicated by HAPC(χ^(2)=0.873;P>0.05).The consistency index of the model was 0.802(95%CI:0.799-0.997),indicating its good accuracy and discrimination.CONCLUSION The column chart model for the p

关 键 词：Anticoagulation therapy Deep vein thrombosis of the lower extremities High-altitude polycythemia Logistic regression analysis Nomogram model Thrombosis recurrence 

分 类 号：R543[医药卫生—心血管疾病]