Clinical effect of botulinum toxin type A combined with autologous fat grafting in patients with nasolabial fold depression  

作　　者：Ru-Jie Wang Ying Wang Jin-Fang Wu Ting-Ting Si 

机构地区：[1]Department of Burns and Plastic Surgery,903rd Hospital of PLA,Hangzhou 310013,Zhejiang Province,China [2]Department of Dermatology,Shanghai Fourth People’s Hospital,Tongji University School of Medicine,Shanghai 200434,China

出　　处：《World Journal of Clinical Cases》2024年第22期4973-4982,共10页世界临床病例杂志

基　　金：Supported by Medical and Health Science and Technology Project of Hangzhou,No.B20230855;Hangzhou Science and Technology Plan Development Project,No.20210133X01.

摘　　要：BACKGROUND Nasolabial fold(NLF)depression can affect the facial appearance of patients to some extent and increase their psychological burdens.In recent years,autologous fat grafting(AFG)combined with botulinum toxin A(BTX-A)injection(AFG+BTX-A injection)has been gradually applied in the treatment of patients with NLF depression.Although studies have been conducted on the efficacy and safety of AFG+BTX-A injection in treating NLF depression,the experimental design,observational indicators,and sample enrollment criteria vary remarkably,making it difficult to draw convincing and consistent conclusions.Thus,further relevant research is warranted.AIM To assess the esthetic improvement,efficacy,and safety of AFG+BTX-A injections in patients with NLF depression.METHODS This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April 2021.These patients were categorized into control(n=30)and observation(n=30)groups.The observation group received AFG+BTX-A injection,whereas the control group underwent AFG only.All patients were evaluated using the wrinkle severity rating scale(WSRS)and global aesthetic improvement scale.The compactness of facial contours,skin evaluation indexes,adverse reactions,and satisfaction of the two groups were evaluated 3 months postoperatively.RESULTS The WSRS scores of the observation group at 1,3,and 6 months postoperatively were lower than those of the control group(P<0.05).Three months postoperatively,facial fine lines and pores showed obvious improvement and the skin index score was higher in the observation group than in the control group(P<0.05).The compactness of facial contours was better in the observation group than in the control group(P<0.05).In addition,no remarkable differences were noted in the incidence of postoperative adverse reactions such as facial stiffness,facial asymmetry,facial bruising,and facial concavity inequality(P>0.05).CONCLUSION AFG+BTX-A injection is a highly safe,cost-effective,effective,and long-lasting treatment

关 键 词：Nasolabial fold depression Botulinum toxin A Autologous fat grafting ESTHETICS SAFETY 

分 类 号：R622[医药卫生—整形外科]