Association between glucose-lowering drugs and circulating insulin antibodies induced by insulin therapy in patients with type 2 diabetes  

作　　者：Peng Zhang Qing Jiang Bo Ding Reng-Na Yan Yun Hu Jian-Hua Ma 

机构地区：[1]Department of Endocrinology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210000,Jiangsu Province,China [2]Department of Endocrinology,The Affiliated Wuxi People's Hospital of Nanjing Medical University,Wuxi Medical Center,Wuxi 214000,Jiangsu Province,China

出　　处：《World Journal of Diabetes》2024年第7期1489-1498,共10页世界糖尿病杂志（英文版）（电子版）

基　　金：Supported by The National Key R and D Program of China,No.2018YFC1314103;The National Natural Science Foundation of China,No.81870563 and No.82270838.

摘　　要：BACKGROUND Insulin antibodies(IAs)affect blood glucose control in patients receiving insulin therapy.AIM To investigate the relationship between different hypoglycemic treatments and IAs in patients with type 2 diabetes mellitus(T2DM).METHODS This cross-sectional,retrospective study included 1863 patients with T2DM who were receiving exogenous insulin therapy.All patients received stable antidiabetic therapy in the last 3 months and IA levels were measured using an iodine-125 array.RESULTS A total of 1863 patients were enrolled.There were 902(48.4%)patients who had positive IAs(IA level>5%),with a mean IA level of 11.06%(10.39%-11.72%).IA levels were positively correlated with high fasting blood glucose(odds ratio=1.069,P<0.001).The proportion of positive IAs was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),P<0.001.The IA levels in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all P<0.05).CONCLUSION Nearly half of patients on insulin therapy have positive IA antibodies,and IA antibody levels are associated with blood glucose control.Insulin glargine and a combination of oral glucose-lowering drugs were correlated with lower IA levels.

关 键 词：Insulin antibodies Insulin therapy Glucose-lowering drugs GLARGINE Type 2 diabetes 

分 类 号：R587.1[医药卫生—内分泌]