Clinical efficacy of laparoscopic cholecystectomy plus cholangioscopy for the treatment of cholecystolithiasis combined with choledocholithiasis  

作　　者：Chao-Hui Liu Zhi-Wei Chen Zhe Yu Hong-Yu Liu Jian-Sheng Pan Shuang-Shuang Qiu 

机构地区：[1]Department of General Surgery,The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force),Quanzhou 362000,Fujian Province,China [2]Department of General Surgery,Anxi Hospital of Traditional Chinese Medicine,Quanzhou 362499,Fujian Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第7期2080-2087,共8页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Currently,endoscopic retrograde cholangiopancreatography(ERCP)plus laparoscopic cholecystectomy(LC)is the main treatment for cholecystolithiasis combined with choledocholithiasis.However,the treatment is unsatisfactory,and the development of better therapies is needed.AIM To determine the clinical efficacy of LC plus cholangioscopy for cholecystolithiasis combined with choledocholithiasis.METHODS Patients(n=243)with cholecystolithiasis and choledocholithiasis admitted to The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)between January 2019 and December 2023 were included in the study;111 patients(control group)underwent ERCP+LC and 132 patients(observation group)underwent LC+laparoscopic common bile duct exploration(LCBDE).Surgical success rates,residual stone rates,complications(pancreatitis,hyperamylasemia,biliary tract infection,and bile leakage),surgical indicators[intraoperative blood loss(IBL)and operation time(OT)],recovery indices(postoperative exhaust/defecation time and hospital stay),and serum inflammatory markers[C-reactive protein(CRP)],tumor necrosis factor-α(TNF-α),and interleukin-6(IL-6)were compared.RESULTS No significant differences in surgical success rates and residual stone rates were detected between the observation and control groups.However,the complication rate,IBL,OT,postoperative exhaust/defecation time,and hospital stays were significantly reduced in the observation group compared with the control group.Furthermore,CRP,TNF-α,and IL-6 Levels after treatment were reduced in the observation group compared with the levels in the control group.CONCLUSION These results indicate that LC+LCBDE is safer than ERCP+LC for the treatment of cholecystolithiasis combined with choledocholithiasis.The surgical risks and postoperative complications were lower in the observation group compared with the control group.Thus,patients may recover quickly with less inflammation after LCBDE.

关 键 词：Laparoscopic common bile duct exploration Endoscopic retrograde cholangiopancreatography Laparoscopic cholecystectomy CHOLECYSTOLITHIASIS CHOLEDOCHOLITHIASIS Clinical efficacy 

分 类 号：R656[医药卫生—外科学]