Establishment and validation of a predictive model for peripherally inserted central catheter-related thrombosis in patients with liver cancer  

作　　者：Xiao-Fei Chen Hao-Jun Wu Tang Li Jia-Bin Liu Wen-Jie Zhou Qiang Guo 

机构地区：[1]Department of Thyroid Surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China [2]The Second Department of General Surgery,Chengdu Shangjinnanfu Hospital,West China Hospital of Sichuan University,Chengdu 611730,Sichuan Province,China [3]Department of Biliary Surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China [4]Department of Hepatobiliary and Pancreatic Surgery,Chengdu Shangjinnanfu Hospital,West China Hospital of Sichuan University,Chengdu 611730,Sichuan Province,China [5]Department of Vascular Surgery,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Gastrointestinal Surgery》2024年第7期2221-2231,共11页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Peripherally inserted central catheters(PICCs)are commonly used in hospitalized patients with liver cancer for the administration of chemotherapy,nutrition,and other medications.However,PICC-related thrombosis is a serious complication that can lead to morbidity and mortality in this patient population.Several risk factors have been identified for the development of PICC-related thrombosis,including cancer type,stage,comorbidities,and catheter characteristics.Understanding these risk factors and developing a predictive model can help healthcare providers identify high-risk patients and implement preventive measures to reduce the incidence of thrombosis.AIM To analyze the influencing factors of PICC-related thrombosis in hospitalized patients with liver cancer,construct a predictive model,and validate it.METHODS Clinical data of hospitalized patients with liver cancer admitted from January 2020 to December 2023 were collected.Thirty-five cases of PICC-related thrombosis in hospitalized patients with liver cancer were collected,and 220 patients who underwent PICC placement during the same period but did not develop PICC-related thrombosis were randomly selected as controls.A total of 255 samples were collected and used as the training set,and 77 cases were collected as the validation set in a 7:3 ratio.General patient information,case data,catheterization data,coagulation indicators,and Autar Thrombosis Risk Assessment Scale scores were analyzed.Univariate and multivariate unconditional logistic regression analyses were performed on relevant factors,and the value of combined indicators in predicting PICC-related thrombosis in hospitalized patients with liver cancer was evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Univariate analysis showed statistically significant differences(P<0.05)in age,sex,Karnofsky performance status score(KPS),bedridden time,activities of daily living impairment,parenteral nutrition,catheter duration,distant metastasis,and bone marrow suppression be

关 键 词：Liver cancer Peripherally inserted central catheters THROMBOSIS Model Verify 

分 类 号：R54[医药卫生—心血管疾病]