Impacts of different pancreatic resection ranges on endocrine function in Suncus murinus  

作　　者：Ru-Jia Li Ting Yang Yu-Hao Zeng Yutaro Natsuyama Ke Ren Jun Li Yuichi Nagakawa Shuang-Qin Yi 

机构地区：[1]Department of Frontier Health Sciences,Graduate School of Human Health Sciences,Tokyo Metropolitan University,Tokyo 116-8551,Japan [2]Faculty of Physical Education,Qujing Normal University,Qujing 655000,Yunnan Province,China [3]School of Medicine,Shanghai Cancer Institute,Shanghai Jiao Tong University,Shanghai 200240,China [4]Department of Gastrointestinal and Pediatric Surgery,Tokyo Medical University,Tokyo 160-0023,Japan

出　　处：《World Journal of Gastrointestinal Surgery》2024年第7期2308-2318,共11页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND Surgical intervention involving the pancreas can lead to impaired glucose tolerance and other types of endocrine dysfunction.The scope of pancreatectomy and whether it includes the ventral pancreas are the key factors in the development of postoperative diabetes.The ventral and dorsal pancreases are almost separated in Suncus murinus(S.murinus).AIM To investigate the effects of different extents of pancreatic resection on endocrine function in S.murinus.METHODS Eight-week-old male S.murinus shrews were randomly divided into three experimental groups according to different pancreatic resection ranges as follows:ventral pancreatectomy(VPx)group;partial pancreatectomy(PPx)group;subtotal pancreatectomy(SPx)group;and a sham-operated group.Postprandial serum insulin,glucagon-like peptide-1(GLP-1),pancreatic polypeptide(PP),and somatostatin(SST)levels,as well as food intake,weight,blood glucose,and glucose tolerance were regularly measured for each animal.RESULTS S.murinus treated with PPx and SPx suffered from varying degrees of impaired glucose tolerance,but only a small proportion of the SPx group developed diabetes.Only S.murinus in the SPx group showed a significant decrease in food intake accompanied by severe weight loss,as well as a significant increase in postprandial serum GLP-1 levels.Postprandial serum PP levels decreased in both the VPx and PPx groups,but not in the SPx group.Postprandial serum SST levels decreased in both VPx and PPx groups,but the decrease was marginal.CONCLUSION Severe weight loss after pancreatectomy may be related to loss of appetite caused by compensatory elevation of GLP-1.PP and GLP-1 may play a role in resisting blood glucose imbalance.

关 键 词：PANCREATECTOMY Glucose homeostasis Endocrine dysfunction Glucagon-like peptide-1 Pancreatic polypeptide 

分 类 号：R657.5[医药卫生—外科学]