Driving forces of continuing evolution of rotaviruses  

作　　者：Mohamad Saifudin Hakim Faris Muhammad Gazali Suci Ardini Widyaningsih Mohammad Khalid Parvez 

机构地区：[1]Postgraduate School of Molecular Medicine,Erasmus MC-University Medical Center,Rotterdam 3015GD,Netherlands [2]Viral Infection Working Group,International Society of Antimicrobial Chemotherapy,London EC4R 9AN,United Kingdom [3]Master Program in Biotechnology,Postgraduate School,Universitas Gadjah Mada,Yogyakarta,55281,Indonesia [4]Master of Medical Sciences in Clinical Investigation,Harvard Medical School,Boston,MA 02115,United States [5]Department of Pharmacognosy,College of Pharmacy,King Saud University,Riyadh,11451,Saudi Arabia

出　　处：《World Journal of Virology》2024年第2期58-70,共13页世界病毒学杂志

摘　　要：Rotaviruses are non-enveloped double-stranded RNA virus that causes acute diarrheal diseases in children(<5 years).More than 90%of the global rotavirus infection in humans was caused by Rotavirus group A.Rotavirus infection has caused more than 200000 deaths annually and predominantly occurs in the low-income countries.Rotavirus evolution is indicated by the strain dynamics or the emergence of the unprecedented strain.The major factors that drive the rotavirus evolution include the genetic shift that is caused by the reassortment mechanism,either in the intra-or the inter-genogroup.However,other factors are also known to have an impact on rotavirus evolution.This review discusses the structure and types,epidemiology,and evolution of rotaviruses.This article also reviews other supplemental factors of rotavirus evolution,such as genetic reassortment,mutation rate,glycan specificity,vaccine introduction,the host immune respo-nses,and antiviral drugs.

关 键 词：ROTAVIRUS Epidemiology EVOLUTION REASSORTMENT Vaccine 

分 类 号：R37[医药卫生—病原生物学]