Exploring the impact of rotavirus vaccination on antibiotic prescription and resistance:A comprehensive systematic review  

作　　者：Lakshmi Venkata Simhachalam Kutikuppala Matei-Alexandru Cozma Gautam Maddineni Harshal Prakash Chorya Nayanika Tummala Swathi Godugu Jyothi Swaroop Chintala Mihnea-Alexandru Găman 

机构地区：[1]Department of General Surgery,Dr NTR University of Health Sciences,Vijayawada 520008,Andhra Pradesh,India [2]Faculty of Medicine,“Carol Davila”University of Medicine and Pharmacy,Bucharest 050474,Romania [3]Department of Gastroenterology,Colentina Clinical Hospital,Bucharest 020125,Romania [4]Department of Internal Medicine,Florida State University,Cape Coral,FL 33909,United States [5]Department of Internal Medicine,Baroda Medical College,Vadodara 390001,Gujarat,India [6]Department of Internal Medicine,GITAM Institute of Medical Sciences and Research(GIMSR),Visakhapatnam 530045,Andhra Pradesh,India [7]Department of Internal Medicine,Zaporozhye State Medical University,Zaporozhye 69000,Ukraine [8]Department of Anesthesiology,Dr NTR University of Health Sciences,Vijayawada 520008,Andhra Pradesh,India [9]Department of Hematology,Center of Hematology and Bone Marrow Transplantation,Fundeni Clinical Institute,Bucharest 022328,Romania

出　　处：《World Journal of Virology》2024年第2期115-122,共8页世界病毒学杂志

摘　　要：BACKGROUND Rotavirus is a highly contagious virus responsible for a significant burden of acute gastroenteritis,particularly among infants and young children worldwide,however,vaccination against this viral agent is available.Several studies have hypothesized that rotavirus vaccination has been linked to lower rates of antibiotic resistance.AIM To assess the relationship between rotavirus vaccination and antibiotic resistance.METHODS The present systematic review was tailored based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines.Several electronic databases(PubMed/MEDLINE,Scopus and Web of Science)were searched independently by two investigators in order to retrieve relevant publications published until April 2023 that investigated the aforementioned research question.RESULTS The comprehensive database search identified a total of 91 records.After the duplicates were removed(n=75),we screened the titles and abstracts of 16 potentially eligible publications.After the irrelevant records were excluded(n=5),we screened the full texts of 11 manuscripts.Finally,5 studies were entered into the qualitative and quantitative analysis.CONCLUSION In conclusion,all the studies support the idea that vaccinations can reduce the need for antibiotic prescriptions which could potentially contribute to mitigating antibiotic resistance.However,to fully comprehend the mechanisms of antibiotic resistance,enhance treatment guidelines,and consider diverse demographic situations,further research is necessary to use evidence-based strategies to fight antibiotic misuse and resistance.

关 键 词：ROTAVIRUS VACCINATION GASTROENTERITIS ANTIBIOTICS Antibiotic resistance DIARRHEA Children 

分 类 号：R373[医药卫生—病原生物学]