Priming mesenchymal stem cells to develop “super stem cells”  

作　　者：Khawaja Husnain Haider 

机构地区：[1]Department of Basic Sciences,Sulaiman AlRajhi University,AlQaseem 52736,Saudi Arabia

出　　处：《World Journal of Stem Cells》2024年第6期623-640,共18页世界干细胞杂志（英文版）（电子版）

摘　　要：The stem cell pre-treatment approaches at cellular and sub-cellular levels encompass physical manipulation of stem cells to growth factor treatment,genetic manipulation,and chemical and pharmacological treatment,each strategy having advantages and limitations.Most of these pre-treatment protocols are non-combinative.This editorial is a continuum of Li et al’s published article and Wan et al’s editorial focusing on the significance of pre-treatment strategies to enhance their stemness,immunoregulatory,and immunosuppressive properties.They have elaborated on the intricacies of the combinative pre-treatment protocol using pro-inflammatory cytokines and hypoxia.Applying a well-defined multi-pronged combinatorial strategy of mesenchymal stem cells(MSCs),pre-treatment based on the mechanistic understanding is expected to develop“Super MSCs”,which will create a transformative shift in MSC-based therapies in clinical settings,potentially revolutionizing the field.Once optimized,the standardized protocols may be used with slight modifications to pre-treat different stem cells to develop“super stem cells”with augmented stemness,functionality,and reparability for diverse clinical applications with better outcomes.

关 键 词：Cell survival Cell therapy PRECONDITIONING Pre-treatment Stem cells Super stem cells 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]