桥本甲状腺炎中辅助T细胞及其细胞因子与腹型肥胖相关  

Association of T helper cells and cytokines with abdominal obesity in Hashimoto′s thyroiditis

作　　者：加孜热亚·再依拿提 李素丽 张凯迪[1,2,3] 马福慧 马国英 郭艳英[1,2,3] Jazyra ZYNAT;LI Suli;ZHANG Kaidi;MA Fuhui;MA Guoying;GUO Yanying(Xinjiang Clinical Research Center for Diabetes,Urumqi 830001;Xinjiang Endocrinology Diabetes Institute,Urumqi 830001;Department of Endocrinology,People′s Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830001,China)

机构地区：[1]新疆糖尿病临床医学研究中心,新疆乌鲁木齐830001 [2]新疆内分泌糖尿病研究所,新疆乌鲁木齐830001 [3]新疆维吾尔自治区人民医院内分泌科,新疆乌鲁木齐830001

出　　处：《基础医学与临床》2024年第8期1120-1125,共6页Basic and Clinical Medicine

基　　金：新疆维吾尔自治区自然科学基金(2020D01C130)。

摘　　要：目的在辅助T细胞及细胞因子层面探讨腹型肥胖与自身免疫性甲状腺疾病相关性。方法收集就诊于新疆维吾尔自治区人民医院甲状腺功能正常的桥本甲状腺炎(HT)合并腹型肥胖患者108例及非腹型肥胖桥本甲状腺炎患者122例的一般资料,测量腹围,桥本甲状腺炎组患者根据是否腹型肥胖分组,检测甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb),采用流式细胞技术检测辅助T细胞比例及比值,采用酶联免疫吸附测定法检测相关细胞因子。结果TgAb阳性组的腹围高于TgAb阴性组(P<0.05)。腹围与IL-4呈显著正相关,与Th1呈负相关。TgAb滴度与Th1、IFN-γ、TNF、IL-2呈显著负相关,与IL-4呈正相关(P<0.05)。校正性别、年龄等因素后发现腹型肥胖、IL-4均为TgAb抗体阳性的影响因素OR=3.080(95%CI:1.022-9.284),OR=1.296(95%CI:1.022-9.284),P值均<0.05。结论腹型肥胖可能是TgAb抗体阳性的影响因素,腹围越大TgAb抗体滴度越高、Th1水平越低、IL-4水平越高。内脏脂肪可能是通过扰乱辅助T细胞途径影响细胞因子这一中间环节,加重甲状腺的自身免疫性损伤。Objective To investigate the correlation between abdominal obesity and autoimmune thyroid disease in the view point of helper T cells and cytokines.Methods Clinical and laboratory data were collected from 108 patients with Hashimoto′s thyroiditis(HT)plus abdominal obesity and 122 patients of Hashimoto′s thyroiditis without abdominal obesity who visited the People′s Hospital of Xinjiang Uygur Autonomous Region and also from the control population.Abdominal circumference was measured,and patients in the HT patients were grouped according to whether they were abdominally obese or not.The thyroglobulin antibody(TgAb)and thyroid peroxidase antibody(TPOAb)were detected,and the ratio of helper T cells and related cytokines were detected by flow cytometry and enzyme-linked immunosorbent assay.Results The abdominal circumference of the TgAb-positive group was higher than that of the TgAb-negative group(P<0.05).Correlation analysis suggested that abdominal circumference was significantly and positively correlated with TgAb and IL-4 but negatively correlated with Th1.After correcting for gender and age,and abdominal obesity and IL-4 were risk factors for TgAb antibody positivity OR=3.080(95%CI:1.022-9.284)and OR=1.296(95%CI:1.022-9.284),both with P<0.05.Conclusions Abdominal obesity may be an influential factor in TgAb antibody positivity,with larger abdominal circumference having higher TgAb antibody titers,lower Th1 levels,and higher IL-4 levels.Visceral adiposity may exacerbate autoimmune damage of thyroid tissue by disruption of helper T cell pathway.

关 键 词：桥本甲状腺炎 甲状腺球蛋白抗体 腹型肥胖 腹围 IL-4 

分 类 号：R581[医药卫生—内分泌]