杜仲防治神经退行性疾病的机制研究进展  

Research progress on mechanism of Eucommiae Cortex in prevention and treatment of neurodegenerative diseases

作　　者：张数 刘向哲[1] ZHANG Shu;LIU Xiangzhe(Encephalopathy Center,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一附属医院脑病中心,河南郑州450000 [2]河南中医药大学第一临床医学院,河南郑州450046

出　　处：《中草药》2024年第12期4268-4275,共8页Chinese Traditional and Herbal Drugs

基　　金：河南省科技公关项目(242102311277);河南省中医药传承与创新人才工程(仲景工程)中医药学科领军人才(豫卫中医函[2021]8号);2023年度河南省“双一流”创建学科中医学科研专项课题(HSRP-DFCTCM-2023-2-18)。

摘　　要：神经退行性疾病发病机制复杂,且大多病程较长、缠绵难愈,对患者身体及心理均可造成一定不良影响。杜仲Eucommiae Cortex是临床上常用的补益类中药材,最早记载于《神农本草经》,被列为上品,具有悠久的药用历史,具有补肝肾、强筋骨、安胎等功效。现代药理学研究发现杜仲及其有效成分具有增强免疫力、抗炎、抗氧化应激等多重作用,对神经退行性疾病的治疗具有多靶点、多通路的优势。综合近10年杜仲防治神经退行性疾病如缺血性脑卒中、阿尔茨海默病、帕金森、癫痫及肌萎缩性侧索硬化的研究进展,对其作用机制进行综述,以期为杜仲在神经系统疾病的临床应用提供参考。The pathogenesis of neurodegenerative diseases is complex,and most of them have a long course and are difficult to heal,which can cause certain adverse effects on the physical and psychological well-being of patients.Duzhong(Eucommiae Cortex)is a common tonic traditional Chinese medicine in clinical practice,which was first recorded in the Shennong’s Classic of Materia Medica,which is listed as the top grade,and has a long history of medicinal use,and its function can nourish the liver and kidneys,strengthen the muscles and bones,and stabilize the fetus.Modern pharmacological studies have found that Eucommiae Cortex and its active ingredients have multiple effects such as enhancing immunity,antitumor,anti-inflammatory,anti-oxidative stress,etc,and have the advantages of multi-target and multi-pathway for the treatment of neurodegenerative diseases.This article summarizes the research reports on the prevention and treatment of neurodegenerative diseases such as ischemic stroke,Alzheimer’s disease,Parkinson’s disease,epilepsy and amyotrophic lateral sclerosis in the past 10 years,and reviews its mechanism of action,in order to provide reference for the clinical application of Eucommiae Cortex in neurological diseases.

关 键 词：杜仲 神经退行性疾病 缺血性脑卒中 阿尔茨海默病 帕金森病 癫痫 肌萎缩性侧索硬化 

分 类 号：R285[医药卫生—中药学]