川西合耳菊中1个新的艾里莫芬烷倍半萜  

A new eremophilane-type sesquiterpenoid from Synotis solidaginea

作　　者：蔡璐瑶 于涵 李召辉 康钦钊 黎坤 尹汐 赵琳 兰小中[3] 何小凤 吕光华[1,2] CAI Luyao;YU Han;LI Zhaohui;KANG Qinzhao;LI Kun;YIN Xi;ZHAO Lin;LAN Xiaozhong;HE Xiaofeng;LYU Guanghua(State Key Laboratory of Southwestern Specialty Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;School of Ethnic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of Tibetan Medicine Resources Conservation and Utilization of Tibet Autonomous Region,Xizang Agriculture and Animal Husbandry University,Nyingchi 860000,China)

机构地区：[1]成都中医药大学药学院/西南特色中药资源国家重点实验室,四川成都611137 [2]成都中医药大学民族医药学院,四川成都611137 [3]西藏农牧学院/西藏自治区藏药资源保护与利用重点实验室,西藏林芝860000

出　　处：《中草药》2024年第11期3593-3601,共9页Chinese Traditional and Herbal Drugs

基　　金：四川省药品监督管理局中药(民族药)标准提升项目(510201201904914);四川省高校科研创新团队建设计划项目(18TD0017)。

摘　　要：目的研究川西合耳菊Synotis solidaginea的化学成分。方法采用硅胶、聚酰胺、反相C_(18)柱色谱及制备高效液相色谱等技术进行分离纯化;根据波谱数据和文献对比进行化合物结构鉴定。结果从川西合耳菊的醋酸乙酯萃取部位共分离得到18个化合物,分别鉴定为(2R,4S,5R,8R,10S)-2-angeloyloxy-8,10-dihydroxy-eremophil-7(11)-en-8,12-olide(1)、(1R,4S,5S,6S,8R,10S)-1,10-epoxy-6,8-dihydroxy-eremophil-7(11)-en-8,12-olide(2)、(4S,5R,8S,10S)-8,10-dihydroxy-eremophil-7(11)-en-8,12-olide(3)、(4S,5R,8R,10S)-10-hydroxy-eremophil-7(11)-en-8,12-olide(4)、橐吾内酯(5)、4,5-O-二咖啡酰奎宁酸甲酯(6)、异绿原酸C(7)、3,5-O-二咖啡酰基奎宁酸甲酯(8)、异绿原酸A(9)、1,4-O-二咖啡酰奎宁酸甲酯(10)、绿原酸(11)、咖啡酰苹果酸(12)、咖啡酸甲酯(13)、反式咖啡酸(14)、山柰酚-3-O-(6''-O-乙酰基)-β-D-吡喃葡萄糖苷(15)、紫云英苷(16)、2-苯乙基-β-D-吡喃葡萄糖苷(17)、桦褐孔菌二糖(18)。结论化合物1为新的艾里莫芬烷倍半萜类化合物,命名为川西合耳菊内酯A;化合物2、4、5、10、12、13、15、17、18为首次从合耳菊属中分离得到。Objective To study the chemical constituents from the plant of Synotis solidaginea.Methods The extract of S.solidagineawas isolated and purified by silica gel,polyamide,C_(18) reversed-phase silica gel,and preparative HPLC.Their structures were identified by comparison of spectral data and literature.Results A total of 18 compounds were isolated from the ethyl acetate extract of S.solidagineaand identified as(2R,4S,5R,8R,10S)-2-angeloyloxy-8,10-dihydroxy-eremophil-7(11)-en-8,12-olide(1),(1R,4S,5S,6S,8R,10S)-1,10-epoxy-6,8-dihydroxy-eremophil-7(11)-en-8,12-olide(2),(4S,5R,8S,10S)-8,10-dihydroxy-eremophil-7(11)-en-8,12-olide(3),(4S,5R,8R,10S)-10-hydroxy-eremophil-7(11)-en-8,12-olide(4),(4S,5R)-eremophil-1(10),7(11),8(9)-trien-8,12-olide(5),4,5-di-O-caffeoylquinic acid methyl ester(6),4,5-di-caffeoylquinic acid(7),3,5-di-O-caffeoylquinic acid methyl ester(8),3,5-di-caffeoylquinic acid(9),1,4-di-O-caffeoylquinic acid methyl ester(10),chlorogenic acid(11),(2'R)-phaselic acid(12),caffeic acid methyl ester(13),transcaffeic acid(14),kaempferol-3-O-(6''-O-acetyl)-β-D-glucopyranoside(15),astragalin(16),2-phenylethyl-β-D-glucopyranoside(17),inotodisaccharide(18).Conclusion Compound 1was a new eremophilane-type sesquiterpenoid and namedsynotisolidolide A,while compounds 2,4,5,10,12,13,15,17and 18were isolated from the genus Synotisfor the first time.

关 键 词：川西合耳菊 艾里莫芬烷倍半萜 川西合耳菊内酯A 1 4-O-二咖啡酰奎宁酸甲酯 咖啡酸甲酯 

分 类 号：R284.1[医药卫生—中药学]