补肾活血中药治疗膝骨性关节炎与骨质疏松症“共病”机制研究进展  

Mechanism of co-morbidity between osteoarthritis of knee and osteoporosis treated with traditional Chinese medicine for tonifying kidney and activating blood

作　　者：杨浩宇 王世坤 杨东元 尹润宇 邹远超 李远栋[1] YANG Haoyu;WANG Shikun;YANG Dongyuan;YIN Runyu;ZOU Yuanchao;LI Yuandong(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381

出　　处：《中草药》2024年第11期3898-3905,共8页Chinese Traditional and Herbal Drugs

基　　金：天津市中医中西医结合科研课题(2021105);天津中医药大学第一附属医院主题案例征集项目(JX2023009);天津市教委教改项目(TJYG020)。

摘　　要：膝骨性关节炎(knee osteoarthritis,KOA)是一种以膝关节软骨退行性病变和继发性骨质增生为特征的慢性关节疾病。骨质疏松症(osteoporosis,OP)是一种代谢性骨病,主要由于骨量丢失与降低、骨组织微结构破坏、骨脆性增加,导致患者容易出现骨折的全身代谢性骨病。KOA与OP在病因、发病机制方面有很多相似之处,2病病机特点均为以肾虚为本、血瘀为标。通过从促进骨修复、抑制骨破坏2方面对补肾活血类中药治疗KOA与OP“共病”作用机制进行归纳总结,为深入研究KOA与OP“共病”机制提供支持与参考。Knee osteoarthritis(KOA)is a chronic joint disease characterized by degenerative cartilage lesions and secondary osteophytes in the knee joint.Osteoporosis(OP)is a metabolic bone disease,which is a systemic metabolic bone disease mainly due to the loss and decrease of bone mass,destruction of bone microstructure,and increase of bone brittleness,resulting in easy fracture of the patient.There are many similarities in the etiology and pathogenesis of KOA and OP,and the pathogenesis of the two diseases is characterized by renal deficiency as the basic principle,and blood stasis as the symptom.By summarizing the mechanism of kidney-tonifying and blood-activating medicinal in the treatment of KOA and OP from the aspects of promoting bone repair and inhibiting bone destruction,we can provide support and reference for the in-depth study of the mechanism of KOA and OP.

关 键 词：膝骨性关节炎 骨质疏松症 补肾活血中药 细胞自噬 激素水平 氧自由基 

分 类 号：R285[医药卫生—中药学]