红芪黄酮类成分药理作用及机制研究进展  

Research progress on pharmacological action and mechanism of Hedysari Radix flavones

作　　者：符凯润 李昕蓉 魏小成 何军刚 贾妙婷 李岩[1] 燕羽婷 谢鑫明 李成义[1] FU Kairun;LI Xinrong;WEI Xiaocheng;HE Jungang;JIA Miaoting;LI Yan;YAN Yuting;XIE Xinming;LI Chengyi(Gansu University of Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000

出　　处：《中草药》2024年第11期3906-3915,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82160730);国家自然科学基金青年科学基金项目(82104345);甘肃省教育厅双一流重大科研项目(GSSYLXM-05);甘肃省科技计划项目(21YF5FA133)。

摘　　要：红芪Hedysari Radix是甘肃的特色药材,也是甘肃道地药材。现代药学研究表明红芪黄酮类是红芪的主要活性成分,包括黄酮、异黄酮、紫檀烷和黄酮醇等,具有抗氧化、改善肺纤维化、抗肿瘤、抗骨质疏松、降低骨骼肌损伤等药理作用,通过对红芪黄酮类成分药理作用的概述,阐明其药理作用的可能机制,为红芪黄酮类成分的进一步研究及临床应用提供理论依据。Hongqi(Hedysari Radix)is a special agricultural product in Gansu,and also a true medicinal material in Gansu.Modern pharmaceutical studies have shown that Hedysari Radix flavones are the main active components of astragalus,including flavonoids,isoflavones,pterocarpan and flavonols,which have pharmacological effects such as anti-oxidation,improvement of pulmonary fibrosis,antitumor,anti-osteoporosis,and reduction of skeletal muscle damage.Through summarizing pharmacological effects of Hedysari Radix flavones,the possible mechanism of pharmacological effects of Hedysari Radix flavones was clarified,which provides theoretical basis for further study and clinical application of Hedysari Radix flavones.

关 键 词：红芪黄酮类 抗氧化 改善肺纤维化 抗肿瘤 抗骨质疏松 毛蕊异黄酮 芒柄花苷 

分 类 号：R285[医药卫生—中药学]