益生菌的抗生物膜活性及其对肠道健康的影响  

The Anti-biofilm Activity of Probiotics and Its Effect on Intestinal Health

作　　者：钟丹 罗国升 朱攀学 常翠维 杨玲媛[1] ZHONG Dan;LUO Guosheng;ZHU Panxue;CHANG Cuiwei;YANG Lingyuan(College of Animal Science and Technology,Hunan Agricultural University,Changsha,Hunan 410128,China;Hunan Perfly Biotech Co.,Changsha,Hunan 410152,China)

机构地区：[1]湖南农业大学动物科学技术学院,湖南长沙410128 [2]湖南普菲克生物科技有限公司,湖南长沙410152

出　　处：《家畜生态学报》2024年第7期80-86,共7页Journal of Domestic Animal Ecology

基　　金：长沙市科技计划重大专项项目(kq2104001);湖南省创新创业技术投资项目(2018GK5009);湖南省省级大学生创新创业训练计划项目基金(S202210537001)。

摘　　要：生物膜是以有组织的结构附着在生物或非生物表面包括肠道表面的细菌种群或群落,易导致致病菌的持续性感染,并且常规的抗菌药物对其无法彻底根除。因此,研究和开发有效的抗生物膜感染策略至关重要。益生菌是对宿主健康有益的微生物,能通过预防和控制致病菌生物膜形成达到促进机体肠道健康的目的。本文综述了细菌生物膜的形成和耐药机制,进一步介绍益生菌的抗生物膜活性及其对维护畜禽肠道健康的应用,为畜禽生产中抗生物膜相关感染的替代策略提供参考。A biofilm is a bacterial population or community that is attached to a biological or non-biological surface including the surface of the intestine.It is the source of persistent bacterial infections,and cannot be completely eradicated by conventional antibiotics.Therefore,it is crucial to conduct research and develop effective anti-biofilm tactics.Probiotics are beneficial microorganisms to the host,which can promote intestinal health by preventing and controlling biofilm formation.This review summarizes the formation and resistance mechanisms of biofilms,and the application of probiotics'antibiofilm activity in maintaining the gastrointestinal health of livestock and poultry,which provides valuable reference for alternative strategies to combat biofilm-related infections in livestock and poultry production.

关 键 词：益生菌 微生态平衡 生物膜 肠道健康 

分 类 号：S811.5[农业科学—畜牧学] S816.7[农业科学—畜牧兽医] S852.6