Prosthetic venous valves for chronic venous insufficiency:Advancements and future design directions  

作　　者：Qiushuo Zong Jing Liu Yunfei Chen Yuanyuan Kong Yiping Dang Zhihong Wang 

机构地区：[1]Department of Vascular Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430022,China [2]Tianjin Key Laboratory of Biomaterial Research,Institute of Biomedical Engineering,Chinese Academy of Medical Sciences and Peking Union Medical College,Tianjin,300192,China [3]Institute of Transplant Medicine,Nankai University School of Medicine,Tianjin,300071,China

出　　处：《Medicine in Novel Technology and Devices》2024年第1期10-22,共13页医学中新技术与新装备（英文）

基　　金：CAMS Innovation Fund for Medical Sciences(no.2022-I2M-1-023);Natural Science Fund for Distinguished Young Scholars of Tianjin(no.22JCJQJC00110);Natural Science Foundation of China(no.32071356,no.82272158,no.82100518);Science&Technology Projects of Tianjin of China(22JCYBJC00050,21JCQNJC01530);Fundamental Research Funds for the Central Universities(no.3332022069);Science&Technology Projects of Hubei Province(2023EHA057).

摘　　要：With the serious aging population and lifestyle changes,chronic venous insufficiency accounts for approximately 25.95%of the population,which may lead to lower limb edema and leg heaviness,as well as severe infections of skin ulcers that can result in sepsis and necessitate amputation.Conservative treatment and other supportive measures can only slow the disease's progression but are unable to drastically reverse it;surgical interventions are rarely used due to the high risk of catastrophic postoperative consequences.As one of the most promising minimally invasive therapies,percutaneous prosthetic valve replacement has emerged in light of this situation,providing novel alternatives for patients with deep venous valve insufficiency.We reviewed the historical prosthetic venous valve designs,including their structure and materials,animal evaluation models,and assessment criteria.On the basis of the findings from in vitro tests,animal studies,and clinical trials,we summarized the major challenges and potential solutions for the development of advanced prosthetic venous valves.

关 键 词：Prosthetic venous valves Interventional venous valves Deep venous valve insufficiency Deep venous valve reflux Valve leaflets Valve design 

分 类 号：R654.4[医药卫生—外科学]