益气活血复方联合西医常规疗法治疗慢性心衰气虚血瘀证患者87例临床观察  

Treatment for 87 Cases of Chronic Heart Failure with Qi Deficiency and Blood Stasis Syndrome Using Yiqi Huoxue Compound Combined with Routine Therapy

作　　者：刘国华[1,3] 宫丽鸿 张艳[2] LIU Guo-hua;GONG Li-hong;ZHANG Yan(Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110847,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110085,China;Zibo First Hospital,Zibo Shandong 255200,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110085 [3]淄博市第一医院,山东淄博255200

出　　处：《时珍国医国药》2024年第5期1171-1174,共4页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(81774157);辽宁省特聘教授项目(21601A10811)。

摘　　要：目的探讨益气活血复方治疗慢性心力衰竭气虚血瘀证患者的临床疗效。方法研究选取就诊于辽宁中医药大学附属医院专家门诊及同期住院并被诊断为慢性心力衰竭气虚血瘀证的患者90例。将90例患者按照就诊及治疗地点不同分为中药组、西药组,每组45例。两组患者均根据指南采用慢性心力衰竭规范化治疗,中药组在此基础上加用益气活血复方,对比两组治疗前后6分钟步行试验(6MWT)、左室射血分数(LVEF)、N末端脑钠肽前体(NT-proBNP)浓度、中医证候积分、基于中国文化改良的明尼苏达心力衰竭生存质量量表(C-MLHFQ)评分等指标变化。结果治疗前,两组患者各项观察指标对比差异无统计学意义,资料具有可比性(P>0.05)。治疗后,与西药组比较,中药组患者6MWT、LVEF、NT-proBNP、中医证候积分、C-MLHFQ等观察指标均优于对照组,差异具有统计学意义(P<0.001)。与本组治疗前比较,两组患者治疗后NT-proBNP、中医证候积分、C-MLHFQ水平均明显降低(P<0.001),而6MWT、LVEF均显著升高(P<0.001);与西药组治疗后比较,中药组患者改善更明显(P<0.001)。结论益气活血复方联合西医常规疗法能够改善慢性心力衰竭气虚血瘀证患者的临床症状,提高患者的运动耐量及生活质量,可以有效改善患者长期预后。Objective To investigate the clinical effect of Yiqi Huoxue Compound(YQHXC)on chronic heart failure with Qi Deficiency and Blood Stasis Syndrome.Methods A total of 90 chronic heart failure patients with Qi Deficiency and Blood Stasis Syndrome who visited the expert clinics and hospitalised of the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine were selected.90 patients were divided into Chinese medicine group and Western medicine group according to different treatment places,45 cases in each group.All the two groups were given standardized treatment according to the guidelines for chronic heart failure.On this basis,the Chinese medicine group was treated with YQHXC,and compared the changing of the 6-minute walk test(6MWT),left ventricular ejection fraction(LVEF),N-terminal brain natriuretic peptide precursor(NT-proBNP),TCM syndrome score,Minnesota Quality of Life Scale for Heart Failure(C-MLHFQ)score based on Chinese culture modification.Results Before treatment,there was no difference in all aspects between the two groups,and thus the data were comparable(P>0.05).After treatment,compared with the Western medicine group,the observation indexes of 6MWT,LVEF,NT-proBNP,TCM syndrome scores,and C-MLHFQ in the Chinese medicine group were better than those in the Western medicine group,and the difference was statistically significant(P<0.001).The two groups presented decreased in NT-proBNP,TCM syndrome scores and C-MLHFQ(P<0.001)while increased in 6MWT and LVEF(P<0.001)after treatment as compared with those before treatment,and the Chinese medicine group had more decrease or increase than the Western medicine group(P<0.001).Conclusion YQHXC combined with conventional Western medicine therapy can improve the clinical symptoms of patients with chronic heart failure with Qi deficiency and Blood stasis,improve the exercise tolerance and the quality of life of the patient,and then effectively improve the long-term prognosis of the chronic heart failure patients.

关 键 词：益气活血复方 慢性心衰 气虚血瘀证 

分 类 号：R4[医药卫生—临床医学] R78