发热伴血小板减少综合征感染防控专家共识  

Expert consensus on prevention and control of severe fever with thrombocytopenia syndrome

作　　者：胡立芬[1,2] 龚磊 李春辉[4] 殷俊[5] 叶英[1,2] 郜玉峰[1,2] 杨帆 李军[7] 瞿婷婷 程君 尹华发[9] 许夕海[1,2] 伍婷[1,2] 崔宁 王刚 黄小平[12] 徐峰 徐静 杨江华 饶建国[16] 朱立雨[17] 刘贞君[18] 吴家兵[3] 刘玮 李家斌[1,2] HU Lifen;GONG Lei;LI Chunhui;YIN Jun;YE Ying;GAO Yufeng;YANG Fan;LI Jun;QU Tingting;CHENG Jun;YIN Huafa;XU Xihai;WU Ting;CUI Ning;WANG Gang;HUANG Xiaoping;XU Feng;XU Jing;YANG Jianghua;RAO Jianguo;ZHU Liyu;LIU Zhenjun;WU Jiabing;LIU Wei;LI Jiabin(Department of Infectious Diseases,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Anhui Province Key Laboratory of Infectious Diseases,Hefei 230022,China;Anhui Center for Disease Control and Prevention,Hefei 230022,China;Infection Control Center,Xiangya Hospital of Central South University,Changsha 410008,China;Hospital Infection-Control Department,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Hospital Infection-Control Department,Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Infectious Diseases,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210006,China;Hospital Infection-Control Department,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China;Department of Infectious Diseases,Public Health Clinical Center of Anhui Province,Hefei 230022,China;Department of Infectious Diseases,The 154th Hospital,Xinyang 464000,China;Department of Infectious Diseases,Qilu Hospital,Shandong University,Jinan 250012,China;Department of Infectious Diseases,The First Affiliated Hospital of Suzhou University,Suzhou 215006,China;Department of Infectious Diseases,The Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China;Department of Infectious Diseases,The First Affiliated Hospital of University of Science and Technology of China,Hefei 230036,China;Department of Infectious Diseases,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China;Department of Infectious Diseases,Lu′an People′s Hospital of Anhui Province,Lu′an 237000,China;Department of Infectious Diseases,Chaohu Hospital of Anhui Medical University,Chaohu 238001,China;Department of Infectious Diseases,Anqing Municipal Hospital,Anqing 246003,

机构地区：[1]安徽医科大学第一附属医院感染病科,合肥230022 [2]感染性疾病安徽省重点实验室,合肥230022 [3]安徽省疾病预防控制中心,合肥230022 [4]中南大学湘雅医院医院感染控制中心,长沙410008 [5]安徽医科大学第一附属医院感染管理科,合肥230022 [6]复旦大学附属华山医院医院感染管理科,上海200040 [7]南京医科大学第一附属医院感染病科,南京210006 [8]浙江大学医学院附属第一医院感染管理科,杭州310003 [9]安徽省公共卫生临床中心感染科,合肥230022 [10]信阳154中心医院感染科,信阳464000 [11]山东大学齐鲁医院感染病科,济南250012 [12]苏州大学附属第一医院感染病科,苏州215006 [13]浙江大学医学院附属第二医院感染病科,杭州310009 [14]中国科学技术大学附属第一医院感染病科,合肥230036 [15]皖南医学院第一附属医院感染性疾病科,芜湖241001 [16]六安市人民医院感染科,六安237000 [17]安徽医科大学附属巢湖医院感染疾病科,巢湖238001 [18]安庆市立医院感染性疾病科,安庆246003 [19]病原微生物生物安全全国重点实验室,军事医学研究院,北京100850

出　　处：《中华疾病控制杂志》2024年第6期621-628,共8页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(82330103,82370016);安徽省重点研究与开发计划项目(2022e07020043);安徽省卫生健康科研重点项目(AHWJ2022a018);安徽省高校自然科学团队项目(2023AH010083)

摘　　要：发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)是主要通过蜱虫叮咬使患者感染大别班达病毒(Dabie bandavirus,DBV)的新发传染病。2009年首次在我国中部地区发热伴白细胞及血小板减少患者的血清中分离到该病原体,现在亚洲多个国家流行,重症患者死亡率高。近10年来,国内外关于DBV因人际传播而引发SFTS聚集性的疫情事件时有发生。尤其重症患者容易引起人际传播事件发生,在其抢救和治疗过程中因防护不规范易发生院内感染而导致医护人员感染病毒。因此,迫切需要制定防控DBV人际传播的合理措施,控制疫情蔓延,对临床SFTS重症患者的管理有重要的指导意义和临床价值。为了更好地规范DBV人际传播防控策略,研究邀请了该领域的知名专家进行深入讨论,在SFTS的流行概况、患者的血液和体液接触传播、病毒气溶胶传播、患者的污染物及遗体处理等关键防控措施方面达成了共识。Severe fever with thrombocytopenia syndrome(SFTS)is an emerging infectious disease caused by Dabie bandavirus(DBV)transmitted through tick bites.It was initially identified in 2009 among febrile patients with leukopenia and thrombocytopenia in central China.SFTS has been recently reported in other Asia countries,resulting in high mortality among severely ill patients.In the recent 10 years,there have been some reports about human-to-human transmission of DBV,particularly among severely ill patients.However,there are currently no established prevention and control measures for medical staff during the clinical treatment for severely ill SFTS patients against human-to-human transmission.Improper precaution measure can cause nosocomial infection of DBV among medical staff during the clinical process of rescue and treatment.Therefore,it is crucial to develop preventive and control measures against DBV′s human-to-human transmission,which would significantly contribute to the management of severely ill SFTS patients.To better regulate the precaution measures strategies against DBV human-to-human transmission,we have invited renowned experts in this field for extensive discussions,and reached a consensus on prevention and control measures concerning SFTS epidemiological features,contact transmission through patient′s blood and bloody secretions,aerosol transmission,as well as patient′s contaminants handling and corpse disposal.

关 键 词：发热伴血小板减少综合征 大别班达病毒 人际传播 防控措施 

分 类 号：R511[医药卫生—内科学]