鲍曼不动杆菌诱导细胞凋亡的相关研究  

STUDY ON APOPTOSIS INDUCED BY ACINETOBATTER BAUMANNII

作　　者：孙利梅 朝鲁门其其格 张晓蒙[2] 刘慧[1] 李如 喇嘉琪 SUN Limei;Chaoumenqiqige;ZHANG Xiaomeng;LIU Hui;LI Ru;LA Jiaqi(College of First Clinical Medical,Inner Mongolia Medical University,Hohhot 010059,China;Unit of Children’sIntensive Care,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010059 [2]内蒙古医科大学附属医院儿童重症监护病房,内蒙古呼和浩特010050

出　　处：《内蒙古医科大学学报》2024年第2期200-203,209,共5页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区自然科学基金项目(2020MS08113);内蒙古自治区蒙医药协同创新中心科学研究项目(MYYXTYB202109);内蒙古医科大学面上项目(YKD2022MS008)。

摘　　要：鲍曼不动杆菌被认为是医院感染的主要潜在致病菌。但在最近几年,由于广谱抗生素的广泛使用,鲍曼不动杆菌已形成多重耐药菌及泛耐药菌,国内外的研究主要聚焦于这种菌的耐药性和流行病学特点,对其致病原理的研究还处于初级阶段。相关研究证实鲍曼不动杆菌的毒力因子可引起宿主细胞发生凋亡。本文旨在对鲍曼不动杆菌引起细胞凋亡的相关机制进行分析总结。Acinetobacter baumannii is considered to be the main potential causative agent of hospital infections,but in the last few years,due to the widespread use of broad-spectrum antibiotics,A.baumannii has formed multidrug-resistant and pan-drug-resistant bacteria,and domestic and international studies have mainly focused on the drug-resistant and epidemio-logical characteristics of this bacterium,while the study of its pathogenicity is still in the primary stage.Relevant studies have confirmed that the virulence factors of A.baumannii can cause apoptosis in host cells.Therefore,the purpose of this review is to analyze and summarize the mechanism of apoptosis caused by A.baumannii.

关 键 词：鲍曼不动杆菌 细胞凋亡 毒力因子 

分 类 号：R378[医药卫生—病原生物学]