鱼类非感染性肠炎模型及其病理研究概述  

An Overview of Researches on Non-infectious Enteritis Models and Involved Pathological Mechanism in Fish

作　　者：赵旭阳 苏潋 祝清松 程莹寅[2] 吴南[2,3,4] 夏晓勤 ZHAO Xuyang;SU Lian;ZHU Qingsong;CHENG Yingyin;WU Nan;XIA Xiaoqin(College of Fisheries and Life Science,Dalian Ocean University,Dalian 116023,China;Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,China;College of Advanced Agricultural Sciences,University of Chinese Academy of Sciences,Beijing 100049,China;Jiangxi Innovation and Incubation Center of Industrial Technologies,China Academy of Sciences,Nanchang 330200,China)

机构地区：[1]大连海洋大学水产与生命学院,辽宁大连116023 [2]中国科学院水生生物研究所,湖北武汉430072 [3]中国科学院大学现代农业科学学院,北京100049 [4]中国科学院江西产业技术创新与育成中心,江西南昌330200

出　　处：《水产学杂志》2024年第3期109-116,共8页Chinese Journal of Fisheries

基　　金：中国科学院江西产业技术创新与育成中心科技支撑产业发展计划项目(ZKYJXZXCY-202210);国家自然科学基金面上项目(31872592).

摘　　要：替代鱼粉的植物性蛋白源成分容易引起鱼类肠道屏障受损,不仅抑制鱼类生长性能,也增加病原入侵的机会,因此养殖鱼类经常出现由肠道炎症引起的大规模发病现象。建立鱼类非感染性肠炎模型极大方便了鱼类肠炎机理研究,近年来基于病理模型的相关研究已成为鱼类免疫学和营养学研究的前沿。本文通过阐述常见的模式鱼和经济鱼肠炎模型,从黏膜免疫、肠道结构、微生物组成等方面分析了肠炎的发病机理,以期为鱼类肠炎的防治及相关病理研究提供参考。In aquaculture,the substitution of fish meal with vegetable protein sources causes the disruption of the intestinal barrier in fish,and further leads to growth inhibition and susceptibility of pathogen.As a result,intestinal inflammation often leads to disease outbreaks in cultured fish.The establishment of fish non-infectious enteritis models facilitates understanding of the mechanism for fish enteritis.Recently,the analysis of intestinal pathology using fish models gradually becomes the research frontier in both fish immunology and nutritional study.Various types of enteritis models in fish,including those in the model organism and commercial fish species,are reviewed for the involved mechanisms,including mucosal immunity,intestinal structure and microbial composition.It is expected that this paper could provide theoretical clues for both preventing and treating of fish enteritis and related symptom.

关 键 词：硬骨鱼类 肠炎模型 分子病理 黏膜免疫 肠道菌群 

分 类 号：S941.3[农业科学—水产养殖]