细菌群体感应信号分子及其检测方法  

Bacterial quorum sensing signal molecule and detection methods

作　　者：李俊伟 凌保东[1,2] LI Jun-wei;LING Bao-dong(School of Pharmacy,Chengdu Medical College,Chengdu 610500,China;Sichuan Provincial Key Laboratory of Structurally Specific Small Molecule Drug Research,Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院药学院,四川成都610500 [2]成都医学院结构特异性小分子药物研究四川省高校重点实验室,四川成都610500

出　　处：《中国感染控制杂志》2024年第7期901-909,共9页Chinese Journal of Infection Control

基　　金：国家自然科学基金面上项目(81373454);成都医学院2023年研究生科研创新基金(YCX2023-01-32)。

摘　　要：群体感应(quorum sensing,QS)是细菌种内与种间传递信息的重要通讯机制,是细菌感染防治的重要靶点。然而,QS网络复杂多样,信号分子种类繁多,含量低,其检测是QS系统研究中的热点和难点。本文对QS信号分子结构和相应检测方法进行综述,并对未来研究方向与存在的问题进行展望,以期为QS系统通路与机制,药学、食品、临床、环境等多个领域的研究提供参考。Quorum sensing(QS)is an important communication mechanism for bacterial intra-and inter-species information transmission,and is an important target for the prevention and control of bacterial infections.However,the QS network is complex and diverse,with a wide variety of low content signaling molecules.The detection of signaling molecules is hot and difficult in the research fields of QS system.In this paper,the structure of QS signaling molecules and corresponding detection methods are reviewed,and the future research direction and existing problems are prospected,so as to provide reference for the research fields in QS system pathway and mechanism,pharmacy,food,clinical practice,environment,et al.

关 键 词：群体感应 信号分子 生物传感器 仪器检测 

分 类 号：R181.32[医药卫生—流行病学]