产气荚膜梭菌毒素疫苗研究进展  

Research progress in Clostridium perfringens toxin vaccines

作　　者：王东 张思雨[1,2] 丁雅文 曾瑾 WANG Dong;ZHANG Si-yu;DING Ya-wen;ZENG Jin(Key Laboratory of Mini-stry of Education for Conservation and Utilization of Special Biological Resources in Western China,Yinchuan 750021,China;School of Life Science,Ningxia University,Yinchuan 750021,China)

机构地区：[1]宁夏大学西部特色生物资源保护与利用教育部重点实验室,宁夏回族自治区银川750021 [2]宁夏大学生命科学学院,宁夏回族自治区银川750021

出　　处：《中国感染控制杂志》2024年第7期910-917,共8页Chinese Journal of Infection Control

基　　金：国家自然科学基金项目(32360882);宁夏回族自治区重点研发计划重点项目(2023BCF01038);宁夏自然科学基金重点项目(2022AAC02019)。

摘　　要：产气荚膜梭菌是一种引起人类和动物肠道感染和组织坏死的重要食源性病原体,致死因子是其产生的多种外毒素。合理使用抗菌药物及健康养殖需求的增加使疫苗预防更为重要。然而,传统的产气荚膜梭菌外毒素疫苗可能存在效果不稳定及残留毒素和甲醛等问题,引发了人们对这些疫苗安全性的担忧。该文系统介绍了产气荚膜梭菌的传统类毒素疫苗、基因工程重组疫苗及基于反向疫苗学和免疫信息学设计的表位肽疫苗最新研究进展,为研发制备有效、安全的新型产气荚膜梭菌毒素疫苗提供新思路。Clostridium perfringens is an important foodborne pathogen that causes intestinal infections and tissue necrosis in both human and animals.A variety of exotoxins it produces are lethal.The increasing demand for ratio-nal use of antimicrobial agents and healthy farming make the implementation of vaccination critically important.However,traditional Clostridium perfringens exotoxin vaccines may have problems such as inconsistent efficacy,residual toxins and formaldehyde,raising concerns about the safety of these vaccines.This article systematically introduces the latest research progress in traditional toxoid vaccine,genetically engineered recombinant vaccines,and epitope peptide vaccines designed based on reverse vaccinology and immunoinformatics for Clostridium perfringens,providing new ideas for the development and preparation of effective and safe novel Clostridium perfringens toxin vaccines.

关 键 词：产气荚膜梭菌 毒素 流行病学 类毒素疫苗 重组疫苗 

分 类 号：R186[医药卫生—流行病学] R378[医药卫生—公共卫生与预防医学]